SRI (sorcin)

2007-02-01  

Identity

HGNC
SRI
LOCATION
7q21.12
LOCUSID
6717
ALIAS
CP-22,CP22,SCN,V19
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 6717
MIM: 182520
HGNC: 11292
Ensembl: ENSG00000075142

Variants:

dbSNP: 6717
ClinVar: 6717
TCGA: ENSG00000075142
COSMIC: SRI

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000075142ENST00000265729P30626
ENSG00000075142ENST00000394641P30626
ENSG00000075142ENST00000419179B4DHQ6
ENSG00000075142ENST00000431660P30626
ENSG00000075142ENST00000457606E9PG82
ENSG00000075142ENST00000490437C9J0K6

Expression (GTEx)

0
50
100
150
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
HemostasisREACTOMER-HSA-109582
Platelet homeostasisREACTOMER-HSA-418346
Platelet calcium homeostasisREACTOMER-HSA-418360
Reduction of cytosolic Ca++ levelsREACTOMER-HSA-418359
Muscle contractionREACTOMER-HSA-397014
Transmembrane transport of small moleculesREACTOMER-HSA-382551
SLC-mediated transmembrane transportREACTOMER-HSA-425407
Transport of inorganic cations/anions and amino acids/oligopeptidesREACTOMER-HSA-425393
Sodium/Calcium exchangersREACTOMER-HSA-425561
Ion channel transportREACTOMER-HSA-983712
Ion transport by P-type ATPasesREACTOMER-HSA-936837
Stimuli-sensing channelsREACTOMER-HSA-2672351
Cardiac conductionREACTOMER-HSA-5576891
Ion homeostasisREACTOMER-HSA-5578775

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
385366592024Sorcin promotes proliferation of hepatocellular carcinoma by regulating VEGFA/B via PI3K pathway.1
385366592024Sorcin promotes proliferation of hepatocellular carcinoma by regulating VEGFA/B via PI3K pathway.1
339604192021The Ca(2+) -binding protein sorcin stimulates transcriptional activity of the unfolded protein response mediator ATF6.2
341630332021A novel homeostatic loop of sorcin drives paclitaxel-resistance and malignant progression via Smad4/ZEB1/miR-142-5p in human ovarian cancer.17
342052072021Sorcin Activates the Brain PMCA and Blocks the Inhibitory Effects of Molecular Markers of Alzheimer's Disease on the Pump Activity.3
339604192021The Ca(2+) -binding protein sorcin stimulates transcriptional activity of the unfolded protein response mediator ATF6.2
341630332021A novel homeostatic loop of sorcin drives paclitaxel-resistance and malignant progression via Smad4/ZEB1/miR-142-5p in human ovarian cancer.17
342052072021Sorcin Activates the Brain PMCA and Blocks the Inhibitory Effects of Molecular Markers of Alzheimer's Disease on the Pump Activity.3
315858962020mir-1 inhibits migration of gastric cancer cells.4
323053372020Profiling calcium-dependent interactions between Sorcin and intrinsically disordered regions of human proteome.5
330605912020Sorcin is an early marker of neurodegeneration, Ca(2+) dysregulation and endoplasmic reticulum stress associated to neurodegenerative diseases.22
315858962020mir-1 inhibits migration of gastric cancer cells.4
323053372020Profiling calcium-dependent interactions between Sorcin and intrinsically disordered regions of human proteome.5
330605912020Sorcin is an early marker of neurodegeneration, Ca(2+) dysregulation and endoplasmic reticulum stress associated to neurodegenerative diseases.22
301444382018Soluble resistance-related calcium-binding protein in cancers.6

Citation

Dessen P

SRI (sorcin)

Atlas Genet Cytogenet Oncol Haematol. 2007-02-01

Online version: http://atlasgeneticsoncology.org/gene/45785/sri-(sorcin)