ADRA1A (adrenoceptor alpha 1A)

2007-02-01  

Identity

HGNC
LOCATION
8p21.2
LOCUSID
ALIAS
ADRA1C,ADRA1L1,ALPHA1AAR

Other Information

Locus ID:

NCBI: 148
MIM: 104221
HGNC: 277
Ensembl: ENSG00000120907

Variants:

dbSNP: 148
ClinVar: 148
TCGA: ENSG00000120907
COSMIC: ADRA1A

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000120907ENST00000276393P35348
ENSG00000120907ENST00000354550P35348
ENSG00000120907ENST00000380572P35348
ENSG00000120907ENST00000380573P35348
ENSG00000120907ENST00000380582P35348
ENSG00000120907ENST00000380586P35348
ENSG00000120907ENST00000380586B0ZBD3
ENSG00000120907ENST00000519096P35348
ENSG00000120907ENST00000519229E7EW16
ENSG00000120907ENST00000521711P35348

Expression (GTEx)

0
5
10
15

Pathways

PathwaySourceExternal ID
Calcium signaling pathwayKEGGko04020
Neuroactive ligand-receptor interactionKEGGko04080
Calcium signaling pathwayKEGGhsa04020
Neuroactive ligand-receptor interactionKEGGhsa04080
Vascular smooth muscle contractionKEGGhsa04270
Vascular smooth muscle contractionKEGGko04270
Salivary secretionKEGGko04970
Salivary secretionKEGGhsa04970
Adrenergic signaling in cardiomyocytesKEGGhsa04261
Adrenergic signaling in cardiomyocytesKEGGko04261
cGMP-PKG signaling pathwayKEGGhsa04022
cGMP-PKG signaling pathwayKEGGko04022
AMPK signaling pathwayKEGGhsa04152
AMPK signaling pathwayKEGGko04152
Signal TransductionREACTOMER-HSA-162582
Signaling by GPCRREACTOMER-HSA-372790
GPCR ligand bindingREACTOMER-HSA-500792
Class A/1 (Rhodopsin-like receptors)REACTOMER-HSA-373076
Amine ligand-binding receptorsREACTOMER-HSA-375280
AdrenoceptorsREACTOMER-HSA-390696
GPCR downstream signalingREACTOMER-HSA-388396
G alpha (q) signalling eventsREACTOMER-HSA-416476
G alpha (12/13) signalling eventsREACTOMER-HSA-416482
Gastrin-CREB signalling pathway via PKC and MAPKREACTOMER-HSA-881907

Protein levels (Protein atlas)

Not detected
Low
Medium
High

PharmGKB

Entity IDNameTypeEvidenceAssociationPKPDPMIDs
PA164712344Alpha-adrenoreceptor antagonistsChemicalPathwayassociated
PA444552HypertensionDiseaseClinicalAnnotationassociatedPD19444285
PA449396dopamineChemicalPathwayassociated
PA449470epinephrineChemicalPathwayassociated
PA450121isoproterenolChemicalPathwayassociated
PA450431methoxamineChemicalPathwayassociated
PA450631nifedipineChemicalClinicalAnnotationassociatedPD19444285
PA450649norepinephrineChemicalPathwayassociated
PA450935phenylephrineChemicalPathwayassociated

References

Pubmed IDYearTitleCitations
188215652008Genome-wide association scan of quantitative traits for attention deficit hyperactivity disorder identifies novel associations and confirms candidate gene associations.133
198745742009Genetical genomic determinants of alcohol consumption in rats and humans.93
199131212009Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip.85
203796142010Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.62
190860532009Identification of new putative susceptibility genes for several psychiatric disorders by association analysis of regulatory and non-synonymous SNPs of 306 genes involved in neurotransmission and neurodevelopment.34
159172352005Selective inhibition of alpha1A-adrenergic receptor signaling by RGS2 association with the receptor third intracellular loop.33
190116822008Potential relevance of alpha(1)-adrenergic receptor autoantibodies in refractory hypertension.32
215719452011α1-adrenergic receptors positively regulate Toll-like receptor cytokine production from human monocytes and macrophages.29
166331402006Risperidone-related weight gain: genetic and nongenetic predictors.26
199199912009{alpha}1-Adrenergic receptor subtypes in nonfailing and failing human myocardium.26

Citation

Dessen P

ADRA1A (adrenoceptor alpha 1A)

Atlas Genet Cytogenet Oncol Haematol. 2007-02-01

Online version: http://atlasgeneticsoncology.org/gene/45787/adra1a-(adrenoceptor-alpha-1a)