NR1I2 (nuclear receptor subfamily 1 group I member 2)

2007-02-01  

Identity

HGNC
NR1I2
LOCATION
3q13.33
LOCUSID
8856
ALIAS
BXR,ONR1,PAR,PAR1,PAR2,PARq,PRR,PXR,SAR,SXR
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 8856
MIM: 603065
HGNC: 7968
Ensembl: ENSG00000144852

Variants:

dbSNP: 8856
ClinVar: 8856
TCGA: ENSG00000144852
COSMIC: NR1I2

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000144852ENST00000337940O75469
ENSG00000144852ENST00000337940F1D8P9
ENSG00000144852ENST00000393716J3KPQ3
ENSG00000144852ENST00000466380H0Y8E2

Expression (GTEx)

0
5
10
15
20
25
30
35
40
45
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Gene ExpressionREACTOMER-HSA-74160
Generic Transcription PathwayREACTOMER-HSA-212436
Nuclear Receptor transcription pathwayREACTOMER-HSA-383280

PharmGKB

Entity IDNameTypeEvidenceAssociationPKPDPMIDs
PA10034bosentanChemicalVipGeneassociated
PA10049cyproteroneChemicalVipGeneassociated
PA10251atazanavirChemicalClinicalAnnotation, DataAnnotationassociatedPKPD18831695, 20921307, 26174719, 26892777
PA10364memantineChemicalClinicalAnnotationassociatedPK23371894
PA116ABCC2GenePathwayassociated21151855
PA123CYP2B6GenePathwayassociated21738081
PA125CYP2C8GenePathwayassociated21151855
PA127840611troleandomycinChemicalVipGeneassociated
PA130CYP3A4GenePathwayassociated21151855, 21738081, 22722338
PA134865839SLCO1B1GeneDataAnnotationassociated
PA146096022forskolinChemicalVipGeneassociated
PA150481189taxanesChemicalMultilinkAnnotationassociated27561454
PA162355520nephrolithiasisDiseaseClinicalAnnotationassociatedPKPD18831695, 20921307, 26174719, 26892777
PA162372840sunitinibChemicalClinicalAnnotationassociatedPD25344452
PA164743137permethrinChemicalVipGeneassociated
PA164745442penicillin vChemicalVipGeneassociated
PA164745513demeclocyclineChemicalVipGeneassociated
PA164746010econazoleChemicalVipGeneassociated
PA164746890temsirolimusChemicalClinicalAnnotationassociatedPKPD28676933
PA164748964sulfisoxazoleChemicalVipGeneassociated
PA164749137cefaclorChemicalVipGeneassociated
PA164749649dicloxacillinChemicalVipGeneassociated
PA164752250bexaroteneChemicalVipGeneassociated
PA164754742oxiconazoleChemicalVipGeneassociated
PA164781042flucloxacillinChemicalClinicalAnnotationassociatedPD20222094
PA164783809rifapentineChemicalVipGeneassociated
PA164924486st. john's wortChemicalVipGeneassociated
PA164925725Toxic liver diseaseDiseaseClinicalAnnotationassociatedPD20222094
PA165111696artemisininChemicalVipGeneassociated
PA165817016Kidney TransplantationDiseaseClinicalAnnotationassociatedPK25271728, 29733390
PA165817398MyelosuppressionDiseaseClinicalAnnotationassociatedPKPD28676933
PA166114961dolutegravirChemicalLabelAnnotationassociated
PA166124386gastrointestinal toxicityDiseaseClinicalAnnotationassociatedPKPD28676933
PA166151827adverse eventsDiseaseClinicalAnnotationassociatedPKPD28676933
PA166156383rs3814055VariantVipGeneassociated16472590, 17828778, 17925385, 18381611, 20107201, 11668216
PA166156451rs12721608VariantVipGeneassociated11668216
PA244ABCC1GenePathwayassociated21151855
PA267ABCB1GeneDataAnnotation, Pathwayassociated21151855
PA390ABCG2GenePathwayassociated21151855
PA443250Acquired Immunodeficiency SyndromeDiseaseClinicalAnnotationassociatedPKPD18831695, 20921307, 26174719, 26892777
PA443340AnemiaDiseaseClinicalAnnotationassociatedPD24193570
PA443512Urinary Bladder NeoplasmsDiseaseClinicalAnnotationassociatedPKPD28676933
PA443750Colitis, UlcerativeDiseaseVipGeneassociated
PA443756Colonic NeoplasmsDiseaseClinicalAnnotationassociatedPKPD27116457
PA443815Crohn DiseaseDiseaseVipGeneassociated
PA443853DementiaDiseaseClinicalAnnotationassociatedPK23371894
PA444065EpilepsyDiseaseClinicalAnnotationassociatedPK23252947
PA445046Nasopharyngeal NeoplasmsDiseaseClinicalAnnotationassociatedPD24193570
PA445062NeoplasmsDiseaseClinicalAnnotationassociatedPD25344452
PA445204Ovarian NeoplasmsDiseaseVipGeneassociated
PA445425Prostatic NeoplasmsDiseaseVipGeneassociated
PA445601OsteosarcomaDiseaseVipGeneassociated
PA446116Inflammatory Bowel DiseasesDiseaseVipGeneassociated
PA446411Endometrial NeoplasmsDiseaseVipGeneassociated
PA446876Substance-Related DisordersDiseaseClinicalAnnotationassociatedPK26129906
PA447199Bipolar DisorderDiseaseClinicalAnnotationassociatedPK26129906
PA447215Psychotic DisordersDiseaseClinicalAnnotationassociatedPK23609392
PA447230HIVDiseaseClinicalAnnotationassociatedPKPD18831695, 20921307, 26174719, 26892777
PA447278DepressionDiseaseClinicalAnnotationassociatedPK26129906
PA448406amoxicillinChemicalVipGeneassociated
PA448419ampicillinChemicalVipGeneassociated
PA448500atorvastatinChemicalVipGeneassociated
PA448681budesonideChemicalVipGeneassociated
PA448785carbamazepineChemicalClinicalAnnotation, Pathway, VipGeneassociatedPK21738081, 23252947
PA448835cefadroxilChemicalVipGeneassociated
PA448868cefuroximeChemicalVipGeneassociated
PA448883cephalexinChemicalVipGeneassociated
PA448890cefradineChemicalVipGeneassociated
PA448964chlorpromazineChemicalVipGeneassociated
PA449014cisplatinChemicalVipGeneassociated
PA449035clindamycinChemicalVipGeneassociated
PA449057clotrimazoleChemicalVipGeneassociated
PA449165cyclophosphamideChemicalVipGeneassociated
PA449167cyclosporineChemicalLiterature, MultilinkAnnotationassociated24088131
PA449247dexamethasoneChemicalVipGeneassociated
PA449307diethylstilbestrolChemicalVipGeneassociated
PA449383docetaxelChemicalClinicalAnnotation, VipGeneassociatedPD24193570
PA449412doxorubicinChemicalMultilinkAnnotationassociated27561454
PA449415doxycyclineChemicalVipGeneassociated
PA449441efavirenzChemicalVipGeneassociated
PA449493erythromycinChemicalVipGeneassociated
PA449685flutamideChemicalVipGeneassociated
PA449688fluvastatinChemicalVipGeneassociated
PA449782glibenclamideChemicalVipGeneassociated
PA449814griseofulvinChemicalVipGeneassociated
PA449905hydrocortisoneChemicalVipGeneassociated
PA449964ifosfamideChemicalVipGeneassociated
PA450085irinotecanChemicalClinicalAnnotation, MultilinkAnnotationassociatedPKPD27116457, 27561454
PA450112isoniazidChemicalVipGeneassociated
PA450131isradipineChemicalVipGeneassociated
PA450180lansoprazoleChemicalVipGeneassociated
PA450272lovastatinChemicalVipGeneassociated
PA450395metforminChemicalPathwayassociated22722338
PA450401methadoneChemicalVipGeneassociated
PA450486metyraponeChemicalVipGeneassociated
PA450494miconazoleChemicalVipGeneassociated
PA450519minocyclineChemicalVipGeneassociated
PA450530modafinilChemicalVipGeneassociated
PA450576nafcillinChemicalVipGeneassociated
PA450616nevirapineChemicalVipGeneassociated
PA450620nicardipineChemicalVipGeneassociated
PA450631nifedipineChemicalVipGeneassociated
PA450704omeprazoleChemicalVipGeneassociated
PA450761paclitaxelChemicalPathway, VipGeneassociated21151855
PA450911phenobarbitalChemicalVipGeneassociated
PA450932phenylbutazoneChemicalVipGeneassociated
PA450947phenytoinChemicalVipGeneassociated
PA450970pioglitazoneChemicalVipGeneassociated
PA451123progesteroneChemicalVipGeneassociated
PA451234repaglinideChemicalClinicalAnnotationassociatedPK23807564
PA451236reserpineChemicalVipGeneassociated
PA451249rifabutinChemicalVipGeneassociated
PA451250rifampinChemicalClinicalAnnotation, VipGeneassociatedPK17925385
PA451257risperidoneChemicalClinicalAnnotationassociatedPK23609392, 26129906
PA451260ritonavirChemicalVipGeneassociated
PA451283rosiglitazoneChemicalVipGeneassociated
PA451305saquinavirChemicalVipGeneassociated
PA451363simvastatinChemicalVipGeneassociated
PA451365sirolimusChemicalClinicalAnnotationassociatedPKPD28676933
PA451483spironolactoneChemicalVipGeneassociated
PA451542sulfamethazineChemicalVipGeneassociated
PA451550sulfinpyrazoneChemicalVipGeneassociated
PA451578tacrolimusChemicalClinicalAnnotationassociatedPKPD25271728, 26882121, 28777242, 29733390
PA451581tamoxifenChemicalVipGeneassociated
PA451614terbinafineChemicalVipGeneassociated
PA451640tetracyclineChemicalVipGeneassociated
PA451728topiramateChemicalVipGeneassociated
PA451799troglitazoneChemicalVipGeneassociated
PA451846valproic acidChemicalVipGeneassociated
PA451877vinblastineChemicalVipGeneassociated
PA451879vincristineChemicalVipGeneassociated
PA451906warfarinChemicalVariantAnnotationnot associatedPD29298995
PA452604xenobioticsChemicalVipGeneassociated

References

Pubmed IDYearTitleCitations
365039262023Pregnane X receptor gene variant rs7643645 and total mortality in subjects with nonalcoholic fatty liver disease.1
369519642023Effect of pregnane X receptor and cytochrome P450 oxidoreductase gene polymorphisms on trough concentrations of rivaroxaban and edoxaban in patients with nonvalvular atrial fibrillation.0
373491142023NEAT1_2 and DAZAP1, Paraspeckle Components, Interact with PXR to Negatively Regulate CYP3A4 Induction.0
365039262023Pregnane X receptor gene variant rs7643645 and total mortality in subjects with nonalcoholic fatty liver disease.1
369519642023Effect of pregnane X receptor and cytochrome P450 oxidoreductase gene polymorphisms on trough concentrations of rivaroxaban and edoxaban in patients with nonvalvular atrial fibrillation.0
373491142023NEAT1_2 and DAZAP1, Paraspeckle Components, Interact with PXR to Negatively Regulate CYP3A4 Induction.0
345043022022Polymorphisms at CYP enzymes, NR1I2 and NR1I3 in association with virologic response to antiretroviral therapy in Brazilian HIV-positive individuals.2
346892562022Expression dynamics of pregnane X receptor-controlled genes in 3D primary human hepatocyte spheroids.0
348622532022Pregnane X Receptor and the Gut-Liver Axis: A Recent Update.9
350533802022Phosphorylation-Induced Ubiquitination and Degradation of PXR through CDK2-TRIM21 Axis.6
351591232022Nuclear Receptor PXR in Drug-Induced Hypercholesterolemia.10
351685172022No Effect of PXR (8055C>T) Polymorphism on the Pharmacokinetic Profiles of Piperaquine in Healthy Chinese Subjects.1
351840412022Distinct Roles of the Sister Nuclear Receptors PXR and CAR in Liver Cancer Development.3
352123712022Molecular basis of crosstalk in nuclear receptors: heterodimerization between PXR and CAR and the implication in gene regulation.12
352960842022The Outer Membrane Lipoprotein Tp0136 Stimulates Human Platelet Activation and Aggregation Through PAR1 to Enhance G(q)/G(i) Signaling.4

Citation

Dessen P

NR1I2 (nuclear receptor subfamily 1 group I member 2)

Atlas Genet Cytogenet Oncol Haematol. 2007-02-01

Online version: http://atlasgeneticsoncology.org/gene/45797/nr1i2-(nuclear-receptor-subfamily-1-group-i-member-2)