JDP2 (Jun dimerization protein 2)

2007-02-01  

Identity

HGNC
JDP2
LOCATION
14q24.3
LOCUSID
122953
ALIAS
JUNDM2
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 122953
MIM: 608657
HGNC: 17546
Ensembl: ENSG00000140044

Variants:

dbSNP: 122953
ClinVar: 122953
TCGA: ENSG00000140044
COSMIC: JDP2

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000140044ENST00000267569Q8WYK2
ENSG00000140044ENST00000419727Q8WYK2
ENSG00000140044ENST00000419727A0A024R6D7
ENSG00000140044ENST00000435893Q8WYK2
ENSG00000140044ENST00000435893A0A024R6D7
ENSG00000140044ENST00000437176Q8WYK2
ENSG00000140044ENST00000437176A0A024R6D7
ENSG00000140044ENST00000559060H0YKE4
ENSG00000140044ENST00000651602Q8WYK2
ENSG00000140044ENST00000651602A0A024R6D7

Expression (GTEx)

0
5
10
15
20
25
30
35
40
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

PharmGKB

Entity IDNameTypeEvidenceAssociationPKPDPMIDs
PA283MAPK8GenePathwayassociated23922006
PA30621MAPK14GenePathwayassociated23922006

References

Pubmed IDYearTitleCitations
146277102004The c-Jun dimerization protein 2 inhibits cell transformation and acts as a tumor suppressor gene.28
195536672009A progesterone receptor co-activator (JDP2) mediates activity through interaction with residues in the carboxyl-terminal extension of the DNA binding domain.20
229899522012The bZIP repressor proteins, c-Jun dimerization protein 2 and activating transcription factor 3, recruit multiple HDAC members to the ATF3 promoter.20
242320972013Jun dimerization protein 2 is a critical component of the Nrf2/MafK complex regulating the response to ROS homeostasis.17
183961632008Role of the repressor JDP2 in the amino acid-regulated transcription of CHOP.13
186719722008IRF2-binding protein-1 is a JDP2 ubiquitin ligase and an inhibitor of ATF2-dependent transcription.11
160268682005Depletion of the AP-1 repressor JDP2 induces cell death similar to apoptosis.9
215250112011Involvement of Jun dimerization protein 2 (JDP2) in the maintenance of Epstein-Barr virus latency.9
206771662010Downregulation of AP-1 repressor JDP2 is associated with tumor metastasis and poor prognosis in patients with pancreatic carcinoma.8
241203782013Preeclamptic plasma induces transcription modifications involving the AP-1 transcriptional regulator JDP2 in endothelial cells.8

Citation

Dessen P

JDP2 (Jun dimerization protein 2)

Atlas Genet Cytogenet Oncol Haematol. 2007-02-01

Online version: http://atlasgeneticsoncology.org/gene/45799/jdp2-(jun-dimerization-protein-2)