Identity
HGNC
LOCATION
1q23.3
LOCUSID
ALIAS
2B4,NAIL,NKR2B4,Nmrk,SLAMF4
FUSION GENES
Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool
Other Information
Locus ID:
NCBI: 51744
MIM: 605554
HGNC: 18171
Ensembl: ENSG00000122223
Variants:
dbSNP: 51744
ClinVar: 51744
TCGA: ENSG00000122223
COSMIC: CD244
RNA/Proteins
| Gene ID | Transcript ID | Uniprot |
|---|---|---|
| ENSG00000122223 | ENST00000322302 | Q9BZW8 |
| ENSG00000122223 | ENST00000368033 | Q9BZW8 |
| ENSG00000122223 | ENST00000368034 | Q9BZW8 |
| ENSG00000122223 | ENST00000492063 | Q9BZW8 |
Expression (GTEx)
Pathways
References
| Pubmed ID | Year | Title | Citations |
|---|---|---|---|
| 37516949 | 2023 | 2B4 inhibits the apoptosis of natural killer cells through phosphorylated extracellular signal-related kinase/B-cell lymphoma 2 signal pathway. | 1 |
| 37634081 | 2023 | Evaluation of mRNA Expression of CD244 and Its Adapter Molecules in CD8+ T Cells in Acute Leukemia. | 0 |
| 37516949 | 2023 | 2B4 inhibits the apoptosis of natural killer cells through phosphorylated extracellular signal-related kinase/B-cell lymphoma 2 signal pathway. | 1 |
| 37634081 | 2023 | Evaluation of mRNA Expression of CD244 and Its Adapter Molecules in CD8+ T Cells in Acute Leukemia. | 0 |
| 33401997 | 2022 | Expression and Clinical Significance of KLRG1 and 2B4 on T Cells in the Peripheral Blood and Tumour of Patients with Cervical Cancer. | 3 |
| 33608984 | 2022 | Increased TOX expression concurrent with PD-1, Tim-3, and CD244 in T cells from patients with non-Hodgkin lymphoma. | 12 |
| 33401997 | 2022 | Expression and Clinical Significance of KLRG1 and 2B4 on T Cells in the Peripheral Blood and Tumour of Patients with Cervical Cancer. | 3 |
| 33608984 | 2022 | Increased TOX expression concurrent with PD-1, Tim-3, and CD244 in T cells from patients with non-Hodgkin lymphoma. | 12 |
| 34691037 | 2021 | NKG2D Engagement Alone Is Sufficient to Activate Cytokine-Induced Killer Cells While 2B4 Only Provides Limited Coactivation. | 10 |
| 34691037 | 2021 | NKG2D Engagement Alone Is Sufficient to Activate Cytokine-Induced Killer Cells While 2B4 Only Provides Limited Coactivation. | 10 |
| 32217758 | 2020 | CD244 represents a new therapeutic target in head and neck squamous cell carcinoma. | 27 |
| 32796294 | 2020 | Brief Report: Diminished Coinhibitory Molecule 2B4 Expression Is Associated With Preserved iNKT Cell Phenotype in HIV Long-Term Nonprogressors. | 0 |
| 33219153 | 2020 | Human innate lymphoid cell precursors express CD48 that modulates ILC differentiation through 2B4 signaling. | 7 |
| 32217758 | 2020 | CD244 represents a new therapeutic target in head and neck squamous cell carcinoma. | 27 |
| 32796294 | 2020 | Brief Report: Diminished Coinhibitory Molecule 2B4 Expression Is Associated With Preserved iNKT Cell Phenotype in HIV Long-Term Nonprogressors. | 0 |
Citation
Dessen P
CD244 (CD244 molecule)
Atlas Genet Cytogenet Oncol Haematol. 2007-02-01
Online version: http://atlasgeneticsoncology.org/gene/45803/cd244-(cd244-molecule)
