TXNDC17 (thioredoxin domain containing 17)

2007-02-01  

Identity

HGNC
TXNDC17
LOCATION
17p13.1
LOCUSID
84817
ALIAS
TRP14,TXNL5
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 84817
MIM: 616967
HGNC: 28218
Ensembl: ENSG00000129235

Variants:

dbSNP: 84817
ClinVar: 84817
TCGA: ENSG00000129235
COSMIC: TXNDC17

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000129235ENST00000250101Q9BRA2
ENSG00000129235ENST00000250101A0A140VJY7
ENSG00000129235ENST00000570330I3L2R6
ENSG00000129235ENST00000574734I3L0K2
ENSG00000129235ENST00000574838I3L3M7

Expression (GTEx)

0
50
100
150
200
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
388118532024TRP14 is the rate-limiting enzyme for intracellular cystine reduction and regulates proteome cysteinylation.0
388118532024TRP14 is the rate-limiting enzyme for intracellular cystine reduction and regulates proteome cysteinylation.0
333590852021Cellular S-denitrosylases: Potential role and interplay of Thioredoxin, TRP14, and Glutaredoxin systems in thiol-dependent protein denitrosylation.4
333590852021Cellular S-denitrosylases: Potential role and interplay of Thioredoxin, TRP14, and Glutaredoxin systems in thiol-dependent protein denitrosylation.4
256074662015TXNDC17 promotes paclitaxel resistance via inducing autophagy in ovarian cancer.85
256074662015TXNDC17 promotes paclitaxel resistance via inducing autophagy in ovarian cancer.85
247782502014Thioredoxin-related protein of 14 kDa is an efficient L-cystine reductase and S-denitrosylase.74
247782502014Thioredoxin-related protein of 14 kDa is an efficient L-cystine reductase and S-denitrosylase.74
185795192008Dynein light chain LC8 negatively regulates NF-kappaB through the redox-dependent interaction with IkappaBalpha.49
185795192008Dynein light chain LC8 negatively regulates NF-kappaB through the redox-dependent interaction with IkappaBalpha.49
146078432004Roles of TRP14, a thioredoxin-related protein in tumor necrosis factor-alpha signaling pathways.29
146078442004Identification and characterization of TRP14, a thioredoxin-related protein of 14 kDa. New insights into the specificity of thioredoxin function.35
153559592004Structural basis of cellular redox regulation by human TRP14.12
146078432004Roles of TRP14, a thioredoxin-related protein in tumor necrosis factor-alpha signaling pathways.29
146078442004Identification and characterization of TRP14, a thioredoxin-related protein of 14 kDa. New insights into the specificity of thioredoxin function.35

Citation

Dessen P

TXNDC17 (thioredoxin domain containing 17)

Atlas Genet Cytogenet Oncol Haematol. 2007-02-01

Online version: http://atlasgeneticsoncology.org/gene/45804/txndc17-(thioredoxin-domain-containing-17)