PVR (PVR cell adhesion molecule)

2007-02-01 Affiliation

Identity

HGNC

PVR

LOCATION

19q13.31

LOCUSID

5817

ALIAS

CD155,HVED,NECL5,Necl-5,PVS,TAGE4

FUSION GENES

Show Gene Fusions

Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool

Other Information

Locus ID:

NCBI: 5817
MIM: 173850
HGNC: 9705
Ensembl: ENSG00000073008

Variants:

dbSNP: 5817
ClinVar: 5817
TCGA: ENSG00000073008
COSMIC: PVR

RNA/Proteins

Gene ID	Transcript ID	Uniprot
ENSG00000073008	ENST00000187830	F8W7D4
ENSG00000073008	ENST00000344956	P15151
ENSG00000073008	ENST00000403059	P15151
ENSG00000073008	ENST00000406449	A0A0A0MSA9
ENSG00000073008	ENST00000425690	A0A0C4DG49
ENSG00000073008	ENST00000587785	K7EMC6

Expression (GTEx)

Adipose - Subcutaneous

Adipose - Visceral

Adrenal Gland

Artery - Aorta

Artery - Tibial

Bladder

Brain - Amygdala

Brain - Anterior cingulate cortex

Brain - Caudate

Brain - Cerebellar Hemisphere

Brain - Cerebellum

Brain - Cortex

Brain - Frontal Cortex

Brain - Hippocampus

Brain - Hypothalamus

Brain - Nucleus accumbens

Brain - Putamen

Brain - Spinal cord

Brain - Substantia nigra

Breast - Mammary Tissue

Cells - Cultured fibroblasts

Cells - EBV - transformed lymphocytes

Cervix - Ectocervix

Cervix - Endocervix

Colon - Sigmoid

Colon - Transverse

Esophagus - Gastroesophageal Junction

Esophagus - Mucosa

Esophagus - Muscularis

Fallopian Tube

Heart - Atrial Appendage

Heart - Left Ventricle

Kidney - Cortex

Kidney - Medulla

Liver

Lung

Minor Salivary Gland

Muscle - Skeletal

Nerve - Tibial

Ovary

Pancreas

Pituitary

Prostate

Skin - Not Sun Exposed

Skin - Sun Exposed

Small Intestine - Terminal Ileum

Spleen

Stomach

Testis

Thyroid

Uterus

Vagina

Whole Blood

Pathways

Pathway	Source	External ID
Cell adhesion molecules (CAMs)	KEGG	ko04514
Cell adhesion molecules (CAMs)	KEGG	hsa04514
Immune System	REACTOME	R-HSA-168256
Adaptive Immune System	REACTOME	R-HSA-1280218
Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell	REACTOME	R-HSA-198933
Cell-Cell communication	REACTOME	R-HSA-1500931
Cell junction organization	REACTOME	R-HSA-446728
Cell-cell junction organization	REACTOME	R-HSA-421270
Adherens junctions interactions	REACTOME	R-HSA-418990
Nectin/Necl trans heterodimerization	REACTOME	R-HSA-420597

Protein levels (Protein atlas)

Not detected

Low

Medium

High

References

Pubmed ID	Year	Title	Citations
12913096	2003	Identification of PVR (CD155) and Nectin-2 (CD112) as cell surface ligands for the human DNAM-1 (CD226) activating molecule.	237
19815499	2009	The interaction of TIGIT with PVR and PVRL2 inhibits human NK cell cytotoxicity.	179
15536144	2005	Analysis of the receptor-ligand interactions in the natural killer-mediated lysis of freshly isolated myeloid or lymphoblastic leukemias: evidence for the involvement of the Poliovirus receptor (CD155) and Nectin-2 (CD112).	106
15640804	2005	Downregulation of natural killer cell-activating ligand CD155 by human cytomegalovirus UL141.	100
19801517	2009	Primary human tumor cells expressing CD155 impair tumor targeting by down-regulating DNAM-1 on NK cells.	74
15136589	2004	DNAM-1 and PVR regulate monocyte migration through endothelial junctions.	67
22301152	2012	The human immunodeficiency virus type 1 Nef and Vpu proteins downregulate the natural killer cell-activating ligand PVR.	67
21383766	2012	Decreased expression of DNAM-1 on NK cells from acute myeloid leukemia patients.	54
24817116	2014	T-cell immunoglobulin and ITIM domain (TIGIT) receptor/poliovirus receptor (PVR) ligand engagement suppresses interferon-γ production of natural killer cells via β-arrestin 2-mediated negative signaling.	48
19011098	2008	Crystal structure of CD155 and electron microscopic studies of its complexes with polioviruses.	45

Citation

Dessen P

PVR (PVR cell adhesion molecule)

Atlas Genet Cytogenet Oncol Haematol. 2007-02-01

Online version: http://atlasgeneticsoncology.org/gene/45814/pvr-(pvr-cell-adhesion-molecule)