COPS5 (COP9 signalosome subunit 5)

2007-02-01  

Identity

HGNC
LOCATION
8q13.1
LOCUSID
ALIAS
CSN5,JAB1,MOV-34,SGN5
FUSION GENES

Other Information

Locus ID:

NCBI: 10987
MIM: 604850
HGNC: 2240
Ensembl: ENSG00000121022

Variants:

dbSNP: 10987
ClinVar: 10987
TCGA: ENSG00000121022
COSMIC: COPS5

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000121022ENST00000357849Q92905
ENSG00000121022ENST00000357849A0A024R7W9
ENSG00000121022ENST00000517406E5RK55
ENSG00000121022ENST00000517736E5RHH5
ENSG00000121022ENST00000518374E5RG35
ENSG00000121022ENST00000518747E5RHF2
ENSG00000121022ENST00000523890E5RFS1

Expression (GTEx)

0
10
20
30
40
50
60
70

Pathways

PathwaySourceExternal ID
Vesicle-mediated transportREACTOMER-HSA-5653656
Membrane TraffickingREACTOMER-HSA-199991
DNA RepairREACTOMER-HSA-73894
Nucleotide Excision RepairREACTOMER-HSA-5696398
Global Genome Nucleotide Excision Repair (GG-NER)REACTOMER-HSA-5696399
DNA Damage Recognition in GG-NERREACTOMER-HSA-5696394
Transcription-Coupled Nucleotide Excision Repair (TC-NER)REACTOMER-HSA-6781827
Formation of TC-NER Pre-Incision ComplexREACTOMER-HSA-6781823
Clathrin-mediated endocytosisREACTOMER-HSA-8856828
Cargo recognition for clathrin-mediated endocytosisREACTOMER-HSA-8856825

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
373655022023Regulatory mechanisms and therapeutic potential of JAB1 in neurological development and disorders.0
373655022023Regulatory mechanisms and therapeutic potential of JAB1 in neurological development and disorders.0
348020332022Prognostic and therapeutic significance of COP9 signalosome subunit CSN5 in prostate cancer.3
352695882022Epigenetic Studies in the Male APP/BIN1/COPS5 Triple-Transgenic Mouse Model of Alzheimer's Disease.5
361000712022METTL3 upregulates COPS5 expression in osteosarcoma in an m(6)A-related manner to promote osteosarcoma progression.3
348020332022Prognostic and therapeutic significance of COP9 signalosome subunit CSN5 in prostate cancer.3
352695882022Epigenetic Studies in the Male APP/BIN1/COPS5 Triple-Transgenic Mouse Model of Alzheimer's Disease.5
361000712022METTL3 upregulates COPS5 expression in osteosarcoma in an m(6)A-related manner to promote osteosarcoma progression.3
335081202021CSN5 Promotes Carcinogenesis of Thyroid Carcinoma Cells Through ANGPTL2.5
337071152021Shikonin-mediated PD-L1 degradation suppresses immune evasion in pancreatic cancer by inhibiting NF-κB/STAT3 and NF-κB/CSN5 signaling pathways.21
340191952021Jab1/Cops5: a promising target for cancer diagnosis and therapy.11
341488792021PD_BiBIM: Biclustering-based biomarker identification in ESCC microarray data.0
343253422021PDIA6 promotes pancreatic cancer progression and immune escape through CSN5-mediated deubiquitination of β-catenin and PD-L1.16
335081202021CSN5 Promotes Carcinogenesis of Thyroid Carcinoma Cells Through ANGPTL2.5
337071152021Shikonin-mediated PD-L1 degradation suppresses immune evasion in pancreatic cancer by inhibiting NF-κB/STAT3 and NF-κB/CSN5 signaling pathways.21

Citation

Dessen P

COPS5 (COP9 signalosome subunit 5)

Atlas Genet Cytogenet Oncol Haematol. 2007-02-01

Online version: http://atlasgeneticsoncology.org/gene/45824/cops5-(cop9-signalosome-subunit-5)