USP11 (ubiquitin specific peptidase 11)

2007-02-01  

Identity

HGNC
LOCATION
Xp11.3
LOCUSID
ALIAS
UHX1
FUSION GENES

Other Information

Locus ID:

NCBI: 8237
MIM: 300050
HGNC: 12609
Ensembl: ENSG00000102226

Variants:

dbSNP: 8237
ClinVar: 8237
TCGA: ENSG00000102226
COSMIC: USP11

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000102226ENST00000218348P51784
ENSG00000102226ENST00000377078Q5JXD3
ENSG00000102226ENST00000377080C9JBP8
ENSG00000102226ENST00000377107G5E9A6

Expression (GTEx)

0
50
100
150
200
250

Pathways

PathwaySourceExternal ID
Metabolism of proteinsREACTOMER-HSA-392499
Protein foldingREACTOMER-HSA-391251
Chaperonin-mediated protein foldingREACTOMER-HSA-390466
Association of TriC/CCT with target proteins during biosynthesisREACTOMER-HSA-390471
Post-translational protein modificationREACTOMER-HSA-597592
DeubiquitinationREACTOMER-HSA-5688426
Ub-specific processing proteasesREACTOMER-HSA-5689880

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
206019372010Ubiquitin-specific proteases 7 and 11 modulate Polycomb regulation of the INK4a tumour suppressor.57
153141552004BRCA2 is ubiquitinated in vivo and interacts with USP11, a deubiquitinating enzyme that exhibits prosurvival function in the cellular response to DNA damage.56
227739472012USP11 augments TGFβ signalling by deubiquitylating ALK5.44
198748892010USP11 negatively regulates TNFalpha-induced NF-kappaB activation by targeting on IkappaBalpha.40
296662782018Deubiquitylation and stabilization of p21 by USP11 is critical for cell-cycle progression and DNA damage responses.28
178979502007The deubiquitinating enzyme USP11 controls an IkappaB kinase alpha (IKKalpha)-p53 signaling pathway in response to tumor necrosis factor alpha (TNFalpha).27
244879622014USP11 regulates PML stability to control Notch-induced malignancy in brain tumours.26
120840152002Structural and functional characterization of the USP11 deubiquitinating enzyme, which interacts with the RanGTP-associated protein RanBPM.25
184080092008USP11 stabilizes HPV-16E7 and further modulates the E7 biological activity.22
233377512013USP-11 as a predictive and prognostic factor following neoadjuvant therapy in women with breast cancer.17

Citation

Dessen P

USP11 (ubiquitin specific peptidase 11)

Atlas Genet Cytogenet Oncol Haematol. 2007-02-01

Online version: http://atlasgeneticsoncology.org/gene/45825/usp11-(ubiquitin-specific-peptidase-11)