KRT8 (keratin 8)

2007-02-01  

Identity

HGNC
KRT8
LOCATION
12q13.13
LOCUSID
3856
ALIAS
CARD2,CK-8,CK8,CYK8,K2C8,K8,KO
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 3856
MIM: 148060
HGNC: 6446
Ensembl: ENSG00000170421

Variants:

dbSNP: 3856
ClinVar: 3856
TCGA: ENSG00000170421
COSMIC: KRT8

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000170421ENST00000293308P05787
ENSG00000170421ENST00000546542F8VQY3
ENSG00000170421ENST00000546826F8VUG2
ENSG00000170421ENST00000546897P05787
ENSG00000170421ENST00000546900F8VP67
ENSG00000170421ENST00000547176H0YIB2
ENSG00000170421ENST00000548998F8W1U3
ENSG00000170421ENST00000552150P05787
ENSG00000170421ENST00000552551P05787
ENSG00000170421ENST00000619952A0A0U1RQU6

Expression (GTEx)

0
50
100
150
200
250
300
350
400
450
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Developmental BiologyREACTOMER-HSA-1266738
KeratinizationREACTOMER-HSA-6805567

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
379959082024A small molecule chaperone rescues keratin-8 mediated trafficking of misfolded podocin to correct genetic Nephrotic Syndrome.0
379959082024A small molecule chaperone rescues keratin-8 mediated trafficking of misfolded podocin to correct genetic Nephrotic Syndrome.0
350409142022Association of Keratin 8 Level in Aqueous Humor With Outcomes of Intravitreal Ranibizumab Treatment for Neovascular Age-Related Macular Degeneration.1
350806912022Autophagosome-lysosome fusion is facilitated by plectin-stabilized actin and keratin 8 during macroautophagic process.5
359582782022Keratin 8 Is an Inflammation-Induced and Prognosis-Related Marker for Pancreatic Adenocarcinoma.1
360452592022Keratin 8 is a scaffolding and regulatory protein of ERAD complexes.0
350409142022Association of Keratin 8 Level in Aqueous Humor With Outcomes of Intravitreal Ranibizumab Treatment for Neovascular Age-Related Macular Degeneration.1
350806912022Autophagosome-lysosome fusion is facilitated by plectin-stabilized actin and keratin 8 during macroautophagic process.5
359582782022Keratin 8 Is an Inflammation-Induced and Prognosis-Related Marker for Pancreatic Adenocarcinoma.1
360452592022Keratin 8 is a scaffolding and regulatory protein of ERAD complexes.0
334722102021The Role of Keratin-8 and Keratin-18 Polymorphisms and Protein Levels in the Occurrence and Progression of Vocal Leukoplakia.1
336910262021A multi-scale integrated analysis identifies KRT8 as a pan-cancer early biomarker.7
334722102021The Role of Keratin-8 and Keratin-18 Polymorphisms and Protein Levels in the Occurrence and Progression of Vocal Leukoplakia.1
336910262021A multi-scale integrated analysis identifies KRT8 as a pan-cancer early biomarker.7
315155572020Keratin 8 Mutations Were Associated With Susceptibility to Chronic Hepatitis B and Related Progression.2

Citation

Dessen P

KRT8 (keratin 8)

Atlas Genet Cytogenet Oncol Haematol. 2007-02-01

Online version: http://atlasgeneticsoncology.org/gene/45828/krt8-(keratin-8)