ST8SIA4 (ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 4)

2007-02-01  

Identity

HGNC
LOCATION
5q21.1
LOCUSID
ALIAS
PST,PST1,SIAT8D,ST8SIA-IV
FUSION GENES

Other Information

Locus ID:

NCBI: 7903
MIM: 602547
HGNC: 10871
Ensembl: ENSG00000113532

Variants:

dbSNP: 7903
ClinVar: 7903
TCGA: ENSG00000113532
COSMIC: ST8SIA4

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000113532ENST00000231461Q92187
ENSG00000113532ENST00000451528Q92187
ENSG00000113532ENST00000523381E5RFK3

Expression (GTEx)

0
5
10
15
20

Pathways

PathwaySourceExternal ID
Metabolism of proteinsREACTOMER-HSA-392499
Post-translational protein modificationREACTOMER-HSA-597592
Asparagine N-linked glycosylationREACTOMER-HSA-446203
Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent proteinREACTOMER-HSA-446193
Synthesis of substrates in N-glycan biosythesisREACTOMER-HSA-446219
Sialic acid metabolismREACTOMER-HSA-4085001
Developmental BiologyREACTOMER-HSA-1266738
Axon guidanceREACTOMER-HSA-422475
NCAM signaling for neurite out-growthREACTOMER-HSA-375165
NCAM1 interactionsREACTOMER-HSA-419037

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
199131212009Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip.85
203796142010Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.62
195788762009The ERAP2 gene is associated with preeclampsia in Australian and Norwegian populations.39
162298222006Association between polymorphisms in the promoter region of the sialyltransferase 8B (SIAT8B) gene and schizophrenia.35
245317162015Modification of sialylation is associated with multidrug resistance in human acute myeloid leukemia.20
183847872008Polysialylated NCAM represses E-cadherin-mediated cell-cell adhesion in pancreatic tumor cells.19
238013312013Polysialic acid on neuropilin-2 is exclusively synthesized by the polysialyltransferase ST8SiaIV and attached to mucin-type o-glycans located between the b2 and c domain.15
193364002009Identification of sequences in the polysialyltransferases ST8Sia II and ST8Sia IV that are required for the protein-specific polysialylation of the neural cell adhesion molecule, NCAM.14
275278562016Upregulation of miR-181c inhibits chemoresistance by targeting ST8SIA4 in chronic myelocytic leukemia.13
280328582016Functional roles of sialylation in breast cancer progression through miR-26a/26b targeting ST8SIA4.13

Citation

Dessen P

ST8SIA4 (ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 4)

Atlas Genet Cytogenet Oncol Haematol. 2007-02-01

Online version: http://atlasgeneticsoncology.org/gene/45830/st8sia4-(st8-alpha-n-acetyl-neuraminide-alpha-2-8-sialyltransferase-4)