CCL20 (C-C motif chemokine ligand 20)

2007-02-01  

Identity

HGNC
CCL20
LOCATION
2q36.3
LOCUSID
6364
ALIAS
CKb4,Exodus,LARC,MIP-3-alpha,MIP-3a,MIP3A,SCYA20,ST38

Other Information

Locus ID:

NCBI: 6364
MIM: 601960
HGNC: 10619
Ensembl: ENSG00000115009

Variants:

dbSNP: 6364
ClinVar: 6364
TCGA: ENSG00000115009
COSMIC: CCL20

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000115009ENST00000358813P78556
ENSG00000115009ENST00000409189P78556
ENSG00000115009ENST00000646475A0A2R8Y806

Expression (GTEx)

0
1
2
3
4
5
6
7
8
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Cytokine-cytokine receptor interactionKEGGko04060
Cytokine-cytokine receptor interactionKEGGhsa04060
Chemokine signaling pathwayKEGGko04062
Chemokine signaling pathwayKEGGhsa04062
Rheumatoid arthritisKEGGko05323
Rheumatoid arthritisKEGGhsa05323
TNF signaling pathwayKEGGhsa04668
TNF signaling pathwayKEGGko04668
Immune SystemREACTOMER-HSA-168256
Cytokine Signaling in Immune systemREACTOMER-HSA-1280215
Signaling by InterleukinsREACTOMER-HSA-449147
Signal TransductionREACTOMER-HSA-162582
Signaling by GPCRREACTOMER-HSA-372790
GPCR ligand bindingREACTOMER-HSA-500792
Class A/1 (Rhodopsin-like receptors)REACTOMER-HSA-373076
Peptide ligand-binding receptorsREACTOMER-HSA-375276
Chemokine receptors bind chemokinesREACTOMER-HSA-380108
GPCR downstream signalingREACTOMER-HSA-388396
G alpha (i) signalling eventsREACTOMER-HSA-418594
Interleukin-10 signalingREACTOMER-HSA-6783783
IL-17 signaling pathwayKEGGko04657
IL-17 signaling pathwayKEGGhsa04657

References

Pubmed IDYearTitleCitations
381975982024Role of the CCL20/CCR6 axis in tubular epithelial cell injury: Kidney-specific translational insights from acute kidney injury to chronic kidney disease.0
383745732024Food protein-induced allergic proctocolitis in infants is associated with low serum levels of macrophage inflammatory protein-3a.0
386005882024VDR promotes pancreatic cancer progression in vivo by activating CCL20-mediated M2 polarization of tumor associated macrophage.0
388099182024TH1L involvement in colorectal cancer pathogenesis by regulation of CCL20 through the NF-κB signalling pathway.1
381975982024Role of the CCL20/CCR6 axis in tubular epithelial cell injury: Kidney-specific translational insights from acute kidney injury to chronic kidney disease.0
383745732024Food protein-induced allergic proctocolitis in infants is associated with low serum levels of macrophage inflammatory protein-3a.0
386005882024VDR promotes pancreatic cancer progression in vivo by activating CCL20-mediated M2 polarization of tumor associated macrophage.0
388099182024TH1L involvement in colorectal cancer pathogenesis by regulation of CCL20 through the NF-κB signalling pathway.1
363984642023CC chemokine ligand 20 (CCL20) positively regulates collagen type I production in 3D skin equivalent tissues.2
372797312023CCL20 inhibition for treating inflammation in ankylosing spondylitis.0
375719852023CCL20 is a potential therapeutic target associated with immune infiltration in breast cancer.1
376860292023Saturated Fat-Mediated Upregulation of IL-32 and CCL20 in Hepatocytes Contributes to Higher Expression of These Fibrosis-Driving Molecules in MASLD.3
377219712023Transcription Factor TCF3 Promotes Macrophage-Mediated Inflammation and MMP Secretion in Abdominal Aortic Aneurysm by Regulating miR-143-5p /CCL20.0
363984642023CC chemokine ligand 20 (CCL20) positively regulates collagen type I production in 3D skin equivalent tissues.2
372797312023CCL20 inhibition for treating inflammation in ankylosing spondylitis.0

Citation

Dessen P

CCL20 (C-C motif chemokine ligand 20)

Atlas Genet Cytogenet Oncol Haematol. 2007-02-01

Online version: http://atlasgeneticsoncology.org/gene/45839/ccl20-(c-c-motif-chemokine-ligand-20)