RBM4 (RNA binding motif protein 4)

2007-02-01  

Identity

HGNC
RBM4
LOCATION
11q13.2
LOCUSID
5936
ALIAS
LARK,RBM4A,ZCCHC21,ZCRB3A
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 5936
MIM: 602571
HGNC: 9901
Ensembl: ENSG00000173933

Variants:

dbSNP: 5936
ClinVar: 5936
TCGA: ENSG00000173933
COSMIC: RBM4

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000173933ENST00000310092Q9BWF3
ENSG00000173933ENST00000396053Q9BWF3
ENSG00000173933ENST00000398692Q9BWF3
ENSG00000173933ENST00000408993Q9BWF3
ENSG00000173933ENST00000409406Q9BWF3
ENSG00000173933ENST00000483858Q9BWF3
ENSG00000173933ENST00000506523D6R9K7
ENSG00000173933ENST00000510173E9PB51
ENSG00000173933ENST00000530235Q9BWF3
ENSG00000173933ENST00000532968Q9BWF3
ENSG00000173933ENST00000578778J3QRR5

Expression (GTEx)

0
10
20
30
40
50
60
70
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Circadian ClockREACTOMER-HSA-400253
BMAL1:CLOCK,NPAS2 activates circadian gene expressionREACTOMER-HSA-1368108

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
252033232014The splicing factor RBM4 controls apoptosis, proliferation, and migration to suppress tumor progression.54
172845902007Cell stress modulates the function of splicing regulatory protein RBM4 in translation control.43
162606242005Exon selection in alpha-tropomyosin mRNA is regulated by the antagonistic action of RBM4 and PTB.33
215187922011RBM4 down-regulates PTB and antagonizes its activity in muscle cell-specific alternative splicing.30
167778442006RBM4 interacts with an intronic element and stimulates tau exon 10 inclusion.23
169348012006WT1 interacts with the splicing protein RBM4 and regulates its ability to modulate alternative splicing in vivo.21
251400422014Elevated SRPK1 lessens apoptosis in breast cancer cells through RBM4-regulated splicing events.21
198016302009RNA-binding motif protein 4 translocates to cytoplasmic granules and suppresses translation via argonaute2 during muscle cell differentiation.20
238971182013MicroRNA-146a and RBM4 form a negative feed-forward loop that disrupts cytokine mRNA translation following TLR4 responses in human THP-1 monocytes.16
187231132009RBM4: a multifunctional RNA-binding protein.14

Citation

Dessen P

RBM4 (RNA binding motif protein 4)

Atlas Genet Cytogenet Oncol Haematol. 2007-02-01

Online version: http://atlasgeneticsoncology.org/gene/45854/rbm4-(rna-binding-motif-protein-4)