Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool
Other Information
Locus ID:
NCBI: 4224
MIM: 600388
HGNC: 7015
Ensembl: ENSG00000112818
Variants:
dbSNP: 4224
ClinVar: 4224
TCGA: ENSG00000112818
COSMIC: MEP1A
RNA/Proteins
| Gene ID | Transcript ID | Uniprot |
|---|---|---|
| ENSG00000112818 | ENST00000230588 | Q16819 |
| ENSG00000112818 | ENST00000611727 | B7ZL91 |
Expression (GTEx)
Pathways
| Pathway | Source | External ID |
|---|---|---|
| Protein digestion and absorption | KEGG | ko04974 |
| Protein digestion and absorption | KEGG | hsa04974 |
Protein levels (Protein atlas)
References
| Pubmed ID | Year | Title | Citations |
|---|---|---|---|
| 27999200 | 2017 | Metalloproteinase meprin α regulates migration and invasion of human hepatocarcinoma cells and is a mediator of the oncoprotein Reptin. | 8 |
| 28502593 | 2017 | Meprin metalloproteases: Molecular regulation and function in inflammation and fibrosis. | 19 |
| 27999200 | 2017 | Metalloproteinase meprin α regulates migration and invasion of human hepatocarcinoma cells and is a mediator of the oncoprotein Reptin. | 8 |
| 28502593 | 2017 | Meprin metalloproteases: Molecular regulation and function in inflammation and fibrosis. | 19 |
| 27378469 | 2016 | Metalloproteases meprin-ɑ (MEP1A) is a prognostic biomarker and promotes proliferation and invasion of colorectal cancer. | 11 |
| 27378469 | 2016 | Metalloproteases meprin-ɑ (MEP1A) is a prognostic biomarker and promotes proliferation and invasion of colorectal cancer. | 11 |
| 24388959 | 2014 | Association of MEP1A gene variants with insulin metabolism in central European women with polycystic ovary syndrome. | 2 |
| 24474695 | 2014 | Meprin metalloproteases inactivate interleukin 6. | 22 |
| 24388959 | 2014 | Association of MEP1A gene variants with insulin metabolism in central European women with polycystic ovary syndrome. | 2 |
| 24474695 | 2014 | Meprin metalloproteases inactivate interleukin 6. | 22 |
| 22326557 | 2012 | TNF-α-induced down-regulation of CDX2 suppresses MEP1A expression in colitis. | 19 |
| 22923609 | 2012 | Meprinα transactivates the epidermal growth factor receptor (EGFR) via ligand shedding, thereby enhancing colorectal cancer cell proliferation and migration. | 17 |
| 22326557 | 2012 | TNF-α-induced down-regulation of CDX2 suppresses MEP1A expression in colitis. | 19 |
| 22923609 | 2012 | Meprinα transactivates the epidermal growth factor receptor (EGFR) via ligand shedding, thereby enhancing colorectal cancer cell proliferation and migration. | 17 |
| 22096485 | 2011 | Enhanced activity of meprin-α, a pro-migratory and pro-angiogenic protease, in colorectal cancer. | 20 |
Citation
Dessen P
MEP1A (meprin A subunit alpha)
Atlas Genet Cytogenet Oncol Haematol. 2007-02-01
Online version: http://atlasgeneticsoncology.org/gene/45861/mep1a-(meprin-a-subunit-alpha)
