IL12RB2 (interleukin 12 receptor subunit beta 2)

2007-02-01  

Identity

HGNC
IL12RB2
LOCATION
1p31.3
LOCUSID
3595
ALIAS
-
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 3595
MIM: 601642
HGNC: 5972
Ensembl: ENSG00000081985

Variants:

dbSNP: 3595
ClinVar: 3595
TCGA: ENSG00000081985
COSMIC: IL12RB2

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000081985ENST00000262345Q99665
ENSG00000081985ENST00000371000Q99665
ENSG00000081985ENST00000441640H0Y5V0
ENSG00000081985ENST00000541374A0A0A0MTN7
ENSG00000081985ENST00000544434Q99665
ENSG00000081985ENST00000648487Q99665

Expression (GTEx)

0
1
2
3
4
5
6
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Cytokine-cytokine receptor interactionKEGGko04060
Jak-STAT signaling pathwayKEGGko04630
Cytokine-cytokine receptor interactionKEGGhsa04060
Jak-STAT signaling pathwayKEGGhsa04630
Inflammatory bowel disease (IBD)KEGGhsa05321
Inflammatory bowel disease (IBD)KEGGko05321
Immune SystemREACTOMER-HSA-168256
Cytokine Signaling in Immune systemREACTOMER-HSA-1280215
Signaling by InterleukinsREACTOMER-HSA-449147
Interleukin-6 family signalingREACTOMER-HSA-6783589
IL-6-type cytokine receptor ligand interactionsREACTOMER-HSA-6788467
Interleukin-12 signalingREACTOMER-HSA-447115
Th1 and Th2 cell differentiationKEGGko04658
Th1 and Th2 cell differentiationKEGGhsa04658

Protein levels (Protein atlas)

Not detected
Low
Medium
High
N/A

References

Pubmed IDYearTitleCitations
363289552023Association between gene polymorphisms of IL-12, IL-12 receptor and IL-27 and organ involvement in Iranian endometriosis patients.0
363289552023Association between gene polymorphisms of IL-12, IL-12 receptor and IL-27 and organ involvement in Iranian endometriosis patients.0
359233562022Role of Genetic Polymorphisms in IL12Rβ2 in Chronic Obstructive Pulmonary Disease.0
359233562022Role of Genetic Polymorphisms in IL12Rβ2 in Chronic Obstructive Pulmonary Disease.0
332879152020Expressions of IL-12 and its receptors in patients with lumbar disc herniation and their relationship with clinical efficacy.0
332879152020Expressions of IL-12 and its receptors in patients with lumbar disc herniation and their relationship with clinical efficacy.0
311582842019Characterization of two novel mutations in IL-12R signaling in MSMD patients.1
311582842019Characterization of two novel mutations in IL-12R signaling in MSMD patients.1
295763222018Evidence for association of STAT4 and IL12RB2 variants with Myasthenia gravis susceptibility: What is the effect on gene expression in thymus?2
299567912018The close association between IL‑12Rβ2 and p38MAPK, and higher expression in the early stages of NSCLC, indicates a good prognosis for survival.3
295763222018Evidence for association of STAT4 and IL12RB2 variants with Myasthenia gravis susceptibility: What is the effect on gene expression in thymus?2
299567912018The close association between IL‑12Rβ2 and p38MAPK, and higher expression in the early stages of NSCLC, indicates a good prognosis for survival.3
274649622017Identification of susceptibility SNPs in IL10 and IL23R-IL12RB2 for Behçet's disease in Han Chinese.17
282993432017Polymorphisms of IL12RB2 May Affect the Natural History of Primary Biliary Cholangitis: A Single Centre Study.4
289475432017H3K27 Methylation Dynamics during CD4 T Cell Activation: Regulation of JAK/STAT and IL12RB2 Expression by JMJD3.15

Citation

Dessen P

IL12RB2 (interleukin 12 receptor subunit beta 2)

Atlas Genet Cytogenet Oncol Haematol. 2007-02-01

Online version: http://atlasgeneticsoncology.org/gene/45862/il12rb2-(interleukin-12-receptor-subunit-beta-2)