TRH (thyrotropin releasing hormone)

2007-02-01  

Identity

HGNC
LOCATION
3q22.1
LOCUSID
ALIAS
Pro-TRH,TRF
FUSION GENES

Other Information

Locus ID:

NCBI: 7200
MIM: 613879
HGNC: 12298
Ensembl: ENSG00000170893

Variants:

dbSNP: 7200
ClinVar: 7200
TCGA: ENSG00000170893
COSMIC: TRH

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000170893ENST00000302649P20396
ENSG00000170893ENST00000507066D6RFM1

Expression (GTEx)

0
5
10
15
20

Pathways

PathwaySourceExternal ID
Signal TransductionREACTOMER-HSA-162582
Signaling by GPCRREACTOMER-HSA-372790
GPCR ligand bindingREACTOMER-HSA-500792
Class A/1 (Rhodopsin-like receptors)REACTOMER-HSA-373076
Peptide ligand-binding receptorsREACTOMER-HSA-375276
GPCR downstream signalingREACTOMER-HSA-388396
G alpha (q) signalling eventsREACTOMER-HSA-416476
Gastrin-CREB signalling pathway via PKC and MAPKREACTOMER-HSA-881907

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
199131212009Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip.85
190860532009Identification of new putative susceptibility genes for several psychiatric disorders by association analysis of regulatory and non-synonymous SNPs of 306 genes involved in neurotransmission and neurodevelopment.34
203989082010Comprehensive copy number variant (CNV) analysis of neuronal pathways genes in psychiatric disorders identifies rare variants within patients.32
204680642010Association study of 182 candidate genes in anorexia nervosa.30
147646292004Role of signal transducer and activator of transcription 3 in regulation of hypothalamic trh gene expression by leptin.21
122709262002Deficiencies in pro-thyrotropin-releasing hormone processing and abnormalities in thermoregulation in Cpefat/fat mice.20
194532612009High-density association study of 383 candidate genes for volumetric BMD at the femoral neck and lumbar spine among older men.20
171372172006Association of sixty-one non-synonymous polymorphisms in forty-one hypertension candidate genes with blood pressure variation and hypertension.13
198259782010Thyrotropin releasing hormone (TRH): a new player in human hair-growth control.12
223788762012Thyrotropin-releasing hormone (TRH) inhibits melanin-concentrating hormone neurons: implications for TRH-mediated anorexic and arousal actions.12

Citation

Dessen P

TRH (thyrotropin releasing hormone)

Atlas Genet Cytogenet Oncol Haematol. 2007-02-01

Online version: http://atlasgeneticsoncology.org/gene/45882/trh-(thyrotropin-releasing-hormone)