TJP1 (tight junction protein 1)

2007-02-01  

Identity

HGNC
TJP1
LOCATION
15q13.1
LOCUSID
7082
ALIAS
ZO-1
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 7082
MIM: 601009
HGNC: 11827
Ensembl: ENSG00000104067

Variants:

dbSNP: 7082
ClinVar: 7082
TCGA: ENSG00000104067
COSMIC: TJP1

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000104067ENST00000346128Q07157
ENSG00000104067ENST00000356107G3V1L9
ENSG00000104067ENST00000400007H0Y3R8
ENSG00000104067ENST00000400011G5E9E7
ENSG00000104067ENST00000495972H0YKB1
ENSG00000104067ENST00000545208Q07157
ENSG00000104067ENST00000558447H0YLT6
ENSG00000104067ENST00000614355A0A087X0K9

Expression (GTEx)

0
10
20
30
40
50
60
70
80
90
100
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Adherens junctionKEGGko04520
Tight junctionKEGGko04530
Gap junctionKEGGko04540
Vibrio cholerae infectionKEGGko05110
Epithelial cell signaling in Helicobacter pylori infectionKEGGko05120
Adherens junctionKEGGhsa04520
Tight junctionKEGGhsa04530
Gap junctionKEGGhsa04540
Vibrio cholerae infectionKEGGhsa05110
Epithelial cell signaling in Helicobacter pylori infectionKEGGhsa05120
Salmonella infectionKEGGko05132
Salmonella infectionKEGGhsa05132
Signal TransductionREACTOMER-HSA-162582
Signaling by HippoREACTOMER-HSA-2028269
Vesicle-mediated transportREACTOMER-HSA-5653656
Membrane TraffickingREACTOMER-HSA-199991
Gap junction trafficking and regulationREACTOMER-HSA-157858
Regulation of gap junction activityREACTOMER-HSA-191650
c-src mediated regulation of Cx43 function and closure of gap junctionsREACTOMER-HSA-191647
Programmed Cell DeathREACTOMER-HSA-5357801
ApoptosisREACTOMER-HSA-109581
Apoptotic execution phaseREACTOMER-HSA-75153
Apoptotic cleavage of cellular proteinsREACTOMER-HSA-111465
Apoptotic cleavage of cell adhesion proteinsREACTOMER-HSA-351906

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

PharmGKB

Entity IDNameTypeEvidenceAssociationPKPDPMIDs
PA447216SchizophreniaDiseaseClinicalAnnotationassociatedPD
PA451257risperidoneChemicalClinicalAnnotationassociatedPD

References

Pubmed IDYearTitleCitations
386301492024circRNA-PTPN4 mediated regulation of FOXO3 and ZO-1 expression: implications for blood-brain barrier integrity and cognitive function in uremic encephalopathy.0
387958252024TJP1 suppresses trophoblast cell invasion by expressing E2F8 in the human placenta.0
386301492024circRNA-PTPN4 mediated regulation of FOXO3 and ZO-1 expression: implications for blood-brain barrier integrity and cognitive function in uremic encephalopathy.0
387958252024TJP1 suppresses trophoblast cell invasion by expressing E2F8 in the human placenta.0
367196642023ZO-1 expression in normal human macula densa: Immunohistochemical and immunofluorescence investigations.1
367682872023Does the Blood-Brain Barrier Integrity Change in Regard to the Onset of Fetal Growth Restriction?1
368970432023Rabeprazole destroyed gastric epithelial barrier function through FOXF1/STAT3-mediated ZO-1 expression.0
369298682023Hypoxic nasopharyngeal carcinoma-derived exosomal miR-455 increases vascular permeability by targeting ZO-1 to promote metastasis.4
369460502023[Porphyromonas gingivalis infection causes umbilical vein endothelial barrier dysfunction in vitro by down-regulating ZO-1, occludin and VE-cadherin expression].1
373548992023Loss of TJP1 disrupts gastrulation patterning and increases differentiation toward the germ cell lineage in human pluripotent stem cells.5
378524242023CLDN6 inhibits colorectal cancer proliferation dependent on restraining p53 ubiquitination via ZO-1/PTEN axis.1
367196642023ZO-1 expression in normal human macula densa: Immunohistochemical and immunofluorescence investigations.1
367682872023Does the Blood-Brain Barrier Integrity Change in Regard to the Onset of Fetal Growth Restriction?1
368970432023Rabeprazole destroyed gastric epithelial barrier function through FOXF1/STAT3-mediated ZO-1 expression.0
369298682023Hypoxic nasopharyngeal carcinoma-derived exosomal miR-455 increases vascular permeability by targeting ZO-1 to promote metastasis.4

Citation

Dessen P

TJP1 (tight junction protein 1)

Atlas Genet Cytogenet Oncol Haematol. 2007-02-01

Online version: http://atlasgeneticsoncology.org/gene/45883/tjp1-(tight-junction-protein-1)