IL1R1 (interleukin 1 receptor type 1)

2007-02-01  

Identity

HGNC
LOCATION
2q12.1
LOCUSID
ALIAS
CD121A,D2S1473,IL-1R-alpha,IL1R,IL1RA,P80
FUSION GENES

Other Information

Locus ID:

NCBI: 3554
MIM: 147810
HGNC: 5993
Ensembl: ENSG00000115594

Variants:

dbSNP: 3554
ClinVar: 3554
TCGA: ENSG00000115594
COSMIC: IL1R1

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000115594ENST00000409288B8ZZ73
ENSG00000115594ENST00000409329B8ZZ73
ENSG00000115594ENST00000409589B9A040
ENSG00000115594ENST00000409929B8ZZW4
ENSG00000115594ENST00000410023P14778
ENSG00000115594ENST00000413623F8WF92
ENSG00000115594ENST00000422532H7BZM5
ENSG00000115594ENST00000424272B8ZZ73
ENSG00000115594ENST00000428279C9J3W8
ENSG00000115594ENST00000430171C9JQ36
ENSG00000115594ENST00000442590C9JWB2
ENSG00000115594ENST00000450319C9J686
ENSG00000115594ENST00000452403C9JW84

Expression (GTEx)

0
50
100
150
200

Pathways

PathwaySourceExternal ID
MAPK signaling pathwayKEGGko04010
Cytokine-cytokine receptor interactionKEGGko04060
Hematopoietic cell lineageKEGGko04640
MAPK signaling pathwayKEGGhsa04010
Cytokine-cytokine receptor interactionKEGGhsa04060
Hematopoietic cell lineageKEGGhsa04640
AmoebiasisKEGGko05146
AmoebiasisKEGGhsa05146
Osteoclast differentiationKEGGko04380
Osteoclast differentiationKEGGhsa04380
HTLV-I infectionKEGGko05166
HTLV-I infectionKEGGhsa05166
NF-kappa B signaling pathwayKEGGhsa04064
NF-kappa B signaling pathwayKEGGko04064
Inflammatory mediator regulation of TRP channelsKEGGhsa04750
Inflammatory mediator regulation of TRP channelsKEGGko04750
Immune SystemREACTOMER-HSA-168256
Cytokine Signaling in Immune systemREACTOMER-HSA-1280215
Signaling by InterleukinsREACTOMER-HSA-449147
Interleukin-1 signalingREACTOMER-HSA-446652
Th17 cell differentiationKEGGko04659
Th17 cell differentiationKEGGhsa04659
Interleukin-10 signalingREACTOMER-HSA-6783783
Fluid shear stress and atherosclerosisKEGGko05418
Fluid shear stress and atherosclerosisKEGGhsa05418

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
176886912007Catabolic cytokine expression in degenerate and herniated human intervertebral discs: IL-1beta and TNFalpha expression profile.181
194880452010Increased excitotoxicity and neuroinflammatory markers in postmortem frontal cortex from bipolar disorder patients.115
177034122007Genetic susceptibility to respiratory syncytial virus bronchiolitis is predominantly associated with innate immune genes.100
163546862006Nox2 and Rac1 regulate H2O2-dependent recruitment of TRAF6 to endosomal interleukin-1 receptor complexes.96
199131212009Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip.85
198199432009Free fatty acids induce a proinflammatory response in islets via the abundantly expressed interleukin-1 receptor I.83
158668762005SIGIRR inhibits interleukin-1 receptor- and toll-like receptor 4-mediated signaling through different mechanisms.62
199656482010Regulating human Th17 cells via differential expression of IL-1 receptor.61
163018602005Genetic variation associated with preterm birth: a HuGE review.60
254538232014Molecular profiling reveals a tumor-promoting phenotype of monocytes and macrophages in human cancer progression.59

Citation

Dessen P

IL1R1 (interleukin 1 receptor type 1)

Atlas Genet Cytogenet Oncol Haematol. 2007-02-01

Online version: http://atlasgeneticsoncology.org/gene/45898/il1r1-(interleukin-1-receptor-type-1)