GAL (galanin and GMAP prepropeptide)

2007-02-01  

Identity

HGNC
LOCATION
11q13.2
LOCUSID
ALIAS
ETL8,GAL-GMAP,GALN,GLNN,GMAP
FUSION GENES

Other Information

Locus ID:

NCBI: 51083
MIM: 137035
HGNC: 4114
Ensembl: ENSG00000069482

Variants:

dbSNP: 51083
ClinVar: 51083
TCGA: ENSG00000069482
COSMIC: GAL

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000069482ENST00000265643P22466

Expression (GTEx)

0
100
200
300
400
500
600

Pathways

PathwaySourceExternal ID
Signal TransductionREACTOMER-HSA-162582
Signaling by GPCRREACTOMER-HSA-372790
GPCR ligand bindingREACTOMER-HSA-500792
Class A/1 (Rhodopsin-like receptors)REACTOMER-HSA-373076
Peptide ligand-binding receptorsREACTOMER-HSA-375276
GPCR downstream signalingREACTOMER-HSA-388396
G alpha (i) signalling eventsREACTOMER-HSA-418594

Protein levels (Protein atlas)

Not detected
Low
Medium
High

PharmGKB

Entity IDNameTypeEvidenceAssociationPKPDPMIDs
PA10402benzodiazepine derivativesChemicalClinicalAnnotationassociatedPD
PA164713257Selective serotonin reuptake inhibitorsChemicalClinicalAnnotationassociatedPD
PA444460Heroin DependenceDiseaseClinicalAnnotationassociatedPD
PA445043Opioid-Related DisordersDiseaseClinicalAnnotationassociated
PA447321Depressive Disorder, MajorDiseaseClinicalAnnotationassociatedPD
PA450522mirtazapineChemicalClinicalAnnotationassociatedPD
PA452229antidepressantsChemicalClinicalAnnotationassociatedPD
PA452618opioidsChemicalClinicalAnnotationassociated
PA452619heroinChemicalClinicalAnnotationassociatedPD

References

Pubmed IDYearTitleCitations
210423172012Genome-wide association study of major depressive disorder: new results, meta-analysis, and lessons learned.163
210423172012Genome-wide association study of major depressive disorder: new results, meta-analysis, and lessons learned.163
185189252008Genetic susceptibility to heroin addiction: a candidate gene association study.99
198745742009Genetical genomic determinants of alcohol consumption in rats and humans.93
199131212009Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip.85
163148722006Association of galanin haplotypes with alcoholism and anxiety in two ethnically distinct populations.36
163148722006Association of galanin haplotypes with alcoholism and anxiety in two ethnically distinct populations.36
190860532009Identification of new putative susceptibility genes for several psychiatric disorders by association analysis of regulatory and non-synonymous SNPs of 306 genes involved in neurotransmission and neurodevelopment.34
204680642010Association study of 182 candidate genes in anorexia nervosa.30
247068712014Brain galanin system genes interact with life stresses in depression-related phenotypes.28

Citation

Dessen P

GAL (galanin and GMAP prepropeptide)

Atlas Genet Cytogenet Oncol Haematol. 2007-02-01

Online version: http://atlasgeneticsoncology.org/gene/45909/gal-(galanin-and-gmap-prepropeptide)