NCR3 (natural cytotoxicity triggering receptor 3)

2007-02-01  

Identity

HGNC
LOCATION
6p21.33
LOCUSID
ALIAS
1C7,CD337,LY117,MALS,NKp30
FUSION GENES

Other Information

Locus ID:

NCBI: 259197
MIM: 611550
HGNC: 19077
Ensembl: ENSG00000204475

Variants:

dbSNP: 259197
ClinVar: 259197
TCGA: ENSG00000204475
COSMIC: NCR3

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000204475ENST00000340027O14931
ENSG00000204475ENST00000376071O14931
ENSG00000204475ENST00000376072O14931
ENSG00000204475ENST00000376073O14931
ENSG00000204475ENST00000376073Q05D23

Expression (GTEx)

0
5
10
15
20
25
30

Pathways

PathwaySourceExternal ID
Natural killer cell mediated cytotoxicityKEGGko04650
Natural killer cell mediated cytotoxicityKEGGhsa04650
Immune SystemREACTOMER-HSA-168256
Adaptive Immune SystemREACTOMER-HSA-1280218
Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cellREACTOMER-HSA-198933

References

Pubmed IDYearTitleCitations
381480732024Altered NCR3 Splice Variants May Result in Deficient NK Cell Function in Renal Cell Carcinoma Patients.1
381480732024Altered NCR3 Splice Variants May Result in Deficient NK Cell Function in Renal Cell Carcinoma Patients.1
377049512023Human NCR3 gene variants rs2736191 and rs11575837 alter longitudinal risk for development of pediatric malaria episodes and severe malarial anemia.0
377049512023Human NCR3 gene variants rs2736191 and rs11575837 alter longitudinal risk for development of pediatric malaria episodes and severe malarial anemia.0
361041132022Multifunctional NK Cell-Engaging Antibodies Targeting EGFR and NKp30 Elicit Efficient Tumor Cell Killing and Proinflammatory Cytokine Release.11
361041132022Multifunctional NK Cell-Engaging Antibodies Targeting EGFR and NKp30 Elicit Efficient Tumor Cell Killing and Proinflammatory Cytokine Release.11
336718362021Secreted Ligands of the NK Cell Receptor NKp30: B7-H6 Is in Contrast to BAG6 Only Marginally Released via Extracellular Vesicles.7
336718362021Secreted Ligands of the NK Cell Receptor NKp30: B7-H6 Is in Contrast to BAG6 Only Marginally Released via Extracellular Vesicles.7
331251012020Oral cancer cell‑derived exosomes modulate natural killer cell activity by regulating the receptors on these cells.17
331251012020Oral cancer cell‑derived exosomes modulate natural killer cell activity by regulating the receptors on these cells.17
303257802019B7-H6-mediated downregulation of NKp30 in natural killer cells contributes to HIV-2 immune escape.7
311010762019Functional capacity of natural killer cells in HTLV-1 associated myelopathy/tropical spastic paraparesis (HAM/TSP) patients.5
311340552019The Natural Cytotoxicity Receptors in Health and Disease.179
303257802019B7-H6-mediated downregulation of NKp30 in natural killer cells contributes to HIV-2 immune escape.7
311010762019Functional capacity of natural killer cells in HTLV-1 associated myelopathy/tropical spastic paraparesis (HAM/TSP) patients.5

Citation

Dessen P

NCR3 (natural cytotoxicity triggering receptor 3)

Atlas Genet Cytogenet Oncol Haematol. 2007-02-01

Online version: http://atlasgeneticsoncology.org/gene/45913/ncr3-(natural-cytotoxicity-triggering-receptor-3)