Identity
HGNC
LOCATION
21q22.13
LOCUSID
ALIAS
BIR1,GIRK-2,GIRK2,KATP-2,KATP2,KCNJ7,KIR3.2,KPLBS,hiGIRK2
FUSION GENES
Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool
Other Information
Locus ID:
NCBI: 3763
MIM: 600877
HGNC: 6267
Ensembl: ENSG00000157542
Variants:
dbSNP: 3763
ClinVar: 3763
TCGA: ENSG00000157542
COSMIC: KCNJ6
RNA/Proteins
| Gene ID | Transcript ID | Uniprot |
|---|---|---|
| ENSG00000157542 | ENST00000609713 | P48051 |
| ENSG00000157542 | ENST00000645093 | P48051 |
Expression (GTEx)
Pathways
PharmGKB
| Entity ID | Name | Type | Evidence | Association | PK | PD | PMIDs |
|---|---|---|---|---|---|---|---|
| PA164712362 | Analgesics | Chemical | ClinicalAnnotation | associated | PD | 19756153, 20220551 | |
| PA444460 | Heroin Dependence | Disease | ClinicalAnnotation | associated | PD | 20220551 | |
| PA445208 | Pain | Disease | ClinicalAnnotation | associated | PD | 19756153, 20220551, 27027462 | |
| PA445210 | Pain, Postoperative | Disease | ClinicalAnnotation | associated | PD | ||
| PA449599 | fentanyl | Chemical | ClinicalAnnotation | associated | PD | ||
| PA450401 | methadone | Chemical | ClinicalAnnotation | associated | PD | 20220551 | |
| PA450550 | morphine | Chemical | ClinicalAnnotation | associated | PD | 27027462 |
References
| Pubmed ID | Year | Title | Citations |
|---|---|---|---|
| 36207584 | 2023 | Alcohol reverses the effects of KCNJ6 (GIRK2) noncoding variants on excitability of human glutamatergic neurons. | 8 |
| 37168492 | 2023 | Oxidation Driven Reversal of PIP(2)-dependent Gating in GIRK2 Channels. | 2 |
| 36207584 | 2023 | Alcohol reverses the effects of KCNJ6 (GIRK2) noncoding variants on excitability of human glutamatergic neurons. | 8 |
| 37168492 | 2023 | Oxidation Driven Reversal of PIP(2)-dependent Gating in GIRK2 Channels. | 2 |
| 36261449 | 2022 | Association of KCNJ6 rs2070995 and methadone response for pain management in advanced cancer at end-of-life. | 0 |
| 36261449 | 2022 | Association of KCNJ6 rs2070995 and methadone response for pain management in advanced cancer at end-of-life. | 0 |
| 31099984 | 2020 | KCNJ6 variants modulate reward-related brain processes and impact executive functions in attention-deficit/hyperactivity disorder. | 7 |
| 31099984 | 2020 | KCNJ6 variants modulate reward-related brain processes and impact executive functions in attention-deficit/hyperactivity disorder. | 7 |
| 30240440 | 2018 | Gi/o-coupled muscarinic receptors co-localize with GIRK channel for efficient channel activation. | 9 |
| 30323262 | 2018 | Association of Kir genes with blood pressure responses to dietary sodium intervention: the GenSalt study. | 2 |
| 30240440 | 2018 | Gi/o-coupled muscarinic receptors co-localize with GIRK channel for efficient channel activation. | 9 |
| 30323262 | 2018 | Association of Kir genes with blood pressure responses to dietary sodium intervention: the GenSalt study. | 2 |
| 27847216 | 2017 | Genetic correlates of the development of theta event related oscillations in adolescents and young adults. | 12 |
| 27993610 | 2017 | A KCNJ6 gene polymorphism modulates theta oscillations during reward processing. | 8 |
| 27847216 | 2017 | Genetic correlates of the development of theta event related oscillations in adolescents and young adults. | 12 |
Citation
Dessen P
KCNJ6 (potassium inwardly rectifying channel subfamily J member 6)
Atlas Genet Cytogenet Oncol Haematol. 2007-02-01
Online version: http://atlasgeneticsoncology.org/gene/45915/kcnj6-(potassium-inwardly-rectifying-channel-subfamily-j-member-6)
