Identity
HGNC
LOCATION
3q21.3
LOCUSID
ALIAS
10-FTHFDH,10-fTHF,FDH,FTHFD
FUSION GENES
Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool
Other Information
Locus ID:
NCBI: 10840
MIM: 600249
HGNC: 3978
Ensembl: ENSG00000144908
Variants:
dbSNP: 10840
ClinVar: 10840
TCGA: ENSG00000144908
COSMIC: ALDH1L1
RNA/Proteins
Expression (GTEx)
Pathways
Protein levels (Protein atlas)
PharmGKB
| Entity ID | Name | Type | Evidence | Association | PK | PD | PMIDs |
|---|---|---|---|---|---|---|---|
| PA447054 | Stroke | Disease | Literature, MultilinkAnnotation | associated | 24651765 | ||
| PA447197 | Attention Deficit Disorder with Hyperactivity | Disease | ClinicalAnnotation | associated | PD | ||
| PA450423 | l-methionine | Chemical | Literature, MultilinkAnnotation | associated | 24651765 | ||
| PA450464 | methylphenidate | Chemical | ClinicalAnnotation | associated | PD |
References
| Pubmed ID | Year | Title | Citations |
|---|---|---|---|
| 36336972 | 2023 | Abnormal downregulation of 10-formyltetrahydrofolate dehydrogenase promotes the progression of oral squamous cell carcinoma by activating PI3K/Akt/Rb pathway. | 2 |
| 37596270 | 2023 | One-carbon metabolizing enzyme ALDH1L1 influences mitochondrial metabolism through 5-aminoimidazole-4-carboxamide ribonucleotide accumulation and serine depletion, contributing to tumor suppression. | 0 |
| 36336972 | 2023 | Abnormal downregulation of 10-formyltetrahydrofolate dehydrogenase promotes the progression of oral squamous cell carcinoma by activating PI3K/Akt/Rb pathway. | 2 |
| 37596270 | 2023 | One-carbon metabolizing enzyme ALDH1L1 influences mitochondrial metabolism through 5-aminoimidazole-4-carboxamide ribonucleotide accumulation and serine depletion, contributing to tumor suppression. | 0 |
| 35460232 | 2022 | Genetic variants in ALDH1L1 and GLDC influence the serine-to-glycine ratio in Hispanic children. | 2 |
| 35460232 | 2022 | Genetic variants in ALDH1L1 and GLDC influence the serine-to-glycine ratio in Hispanic children. | 2 |
| 32392189 | 2020 | [Functional Hypermethylation of ALDH1L1, PLCL2, and PPP2R3A in Colon Cancer]. | 3 |
| 32392189 | 2020 | [Functional Hypermethylation of ALDH1L1, PLCL2, and PPP2R3A in Colon Cancer]. | 3 |
| 28414156 | 2017 | Modeling of interactions between functional domains of ALDH1L1. | 3 |
| 28714006 | 2017 | ALDH1L1 variant rs2276724 and mRNA expression predict post-operative clinical outcomes and are associated with TP53 expression in HBV-related hepatocellular carcinoma. | 7 |
| 28414156 | 2017 | Modeling of interactions between functional domains of ALDH1L1. | 3 |
| 28714006 | 2017 | ALDH1L1 variant rs2276724 and mRNA expression predict post-operative clinical outcomes and are associated with TP53 expression in HBV-related hepatocellular carcinoma. | 7 |
| 26993122 | 2016 | Association between ALDH1L1 gene polymorphism and neural tube defects in the Chinese Han population. | 3 |
| 27015121 | 2016 | Mining distinct aldehyde dehydrogenase 1 (ALDH1) isoenzymes in gastric cancer. | 17 |
| 27384481 | 2016 | Aldehyde dehydrogenase inhibition combined with phenformin treatment reversed NSCLC through ATP depletion. | 37 |
Citation
Dessen P
ALDH1L1 (aldehyde dehydrogenase 1 family member L1)
Atlas Genet Cytogenet Oncol Haematol. 2007-02-01
Online version: http://atlasgeneticsoncology.org/gene/45920/aldh1l1-(aldehyde-dehydrogenase-1-family-member-l1)
