ASCL2 (achaete-scute family bHLH transcription factor 2)

2007-02-01  

Identity

HGNC
LOCATION
11p15.5
LOCUSID
ALIAS
ASH2,HASH2,MASH2,bHLHa45

Other Information

Locus ID:

NCBI: 430
MIM: 601886
HGNC: 739
Ensembl: ENSG00000183734

Variants:

dbSNP: 430
ClinVar: 430
TCGA: ENSG00000183734
COSMIC: ASCL2

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000183734ENST00000331289Q99929

Expression (GTEx)

0
5
10
15

References

Pubmed IDYearTitleCitations
244635182014Transcription factor achaete-scute homologue 2 initiates follicular T-helper-cell development.118
165680952006Achaete-scute like 2 (ascl2) is a target of Wnt signalling and is upregulated in intestinal neoplasia.41
204792152010Expression of an ASCL2 related stem cell signature and IGF2 in colorectal cancer liver metastases with 11p15.5 gain.34
253712002014MicroRNA-200 (miR-200) cluster regulation by achaete scute-like 2 (Ascl2): impact on the epithelial-mesenchymal transition in colon cancer cells.32
223841702012Ascl2 knockdown results in tumor growth arrest by miRNA-302b-related inhibition of colon cancer progenitor cells.30
129173342003USF1 and USF2 mediate inhibition of human trophoblast differentiation and CYP19 gene expression by Mash-2 and hypoxia.19
252777752015SNAIL1 combines competitive displacement of ASCL2 and epigenetic mechanisms to rapidly silence the EPHB3 tumor suppressor in colorectal cancer.16
258662542015SEMA3F prevents metastasis of colorectal cancer by PI3K-AKT-dependent down-regulation of the ASCL2-CXCR4 axis.14
231812702013Aberrant upregulation of ASCL2 by promoter demethylation promotes the growth and resistance to 5-fluorouracil of gastric cancer cells.11
272926382016A Positive Regulatory Loop between a Wnt-Regulated Non-coding RNA and ASCL2 Controls Intestinal Stem Cell Fate.11

Citation

Dessen P

ASCL2 (achaete-scute family bHLH transcription factor 2)

Atlas Genet Cytogenet Oncol Haematol. 2007-02-01

Online version: http://atlasgeneticsoncology.org/gene/45922/ascl2-(achaete-scute-family-bhlh-transcription-factor-2)