GOPC (golgi associated PDZ and coiled-coil motif containing)

2007-02-01  

Identity

HGNC
LOCATION
6q22.1
LOCUSID
ALIAS
CAL,FIG,GOPC1,PIST,dJ94G16.2
FUSION GENES

Other Information

Locus ID:

NCBI: 57120
MIM: 606845
HGNC: 17643
Ensembl: ENSG00000047932

Variants:

dbSNP: 57120
ClinVar: 57120
TCGA: ENSG00000047932
COSMIC: GOPC

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000047932ENST00000052569Q9HD26
ENSG00000047932ENST00000368498Q9HD26
ENSG00000047932ENST00000535237F5H1Y4

Expression (GTEx)

0
10
20
30
40
50
60
70
80

Pathways

PathwaySourceExternal ID
Signal TransductionREACTOMER-HSA-162582
Signaling by Rho GTPasesREACTOMER-HSA-194315
RHO GTPase EffectorsREACTOMER-HSA-195258
RHO GTPases regulate CFTR traffickingREACTOMER-HSA-5627083

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
126610062003Fusion of FIG to the receptor tyrosine kinase ROS in a glioblastoma with an interstitial del(6)(q21q21).68
187546782008The relative binding affinities of PDZ partners for CFTR: a biochemical basis for efficient endocytic recycling.55
145709152004Modulation of mature cystic fibrosis transmembrane regulator protein by the PDZ domain protein CAL.49
201300902010Syntaxin 6 and CAL mediate the degradation of the cystic fibrosis transmembrane conductance regulator.37
171588662007Targeting CAL as a negative regulator of DeltaF508-CFTR cell-surface expression: an RNA interference and structure-based mutagenetic approach.34
211050332010A stabilizing influence: CAL PDZ inhibition extends the half-life of ΔF508-CFTR.33
160121702005Interactions with PDZ domain proteins PIST/GOPC and PDZK1 regulate intracellular sorting of the somatostatin receptor subtype 5.29
241547282013Mouse model of intrahepatic cholangiocarcinoma validates FIG-ROS as a potent fusion oncogene and therapeutic target.26
153587752004Interaction with cystic fibrosis transmembrane conductance regulator-associated ligand (CAL) inhibits beta1-adrenergic receptor surface expression.24
238189892013Ubiquitination and degradation of CFTR by the E3 ubiquitin ligase MARCH2 through its association with adaptor proteins CAL and STX6.21

Citation

Dessen P

GOPC (golgi associated PDZ and coiled-coil motif containing)

Atlas Genet Cytogenet Oncol Haematol. 2007-02-01

Online version: http://atlasgeneticsoncology.org/gene/45928/gopc-(golgi-associated-pdz-and-coiled-coil-motif-containing)