CRTAM (cytotoxic and regulatory T cell molecule)

2007-02-01  

Identity

HGNC
LOCATION
11q24.1
LOCUSID
ALIAS
CD355
FUSION GENES

Other Information

Locus ID:

NCBI: 56253
MIM: 612597
HGNC: 24313
Ensembl: ENSG00000109943

Variants:

dbSNP: 56253
ClinVar: 56253
TCGA: ENSG00000109943
COSMIC: CRTAM

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000109943ENST00000227348O95727
ENSG00000109943ENST00000533709O95727

Expression (GTEx)

0
50
100
150
200
250

Pathways

PathwaySourceExternal ID
Immune SystemREACTOMER-HSA-168256
Adaptive Immune SystemREACTOMER-HSA-1280218
Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cellREACTOMER-HSA-198933

References

Pubmed IDYearTitleCitations
157814512005Nectin-like protein 2 defines a subset of T-cell zone dendritic cells and is a ligand for class-I-restricted T-cell-associated molecule.61
158119522005The tumor suppressor TSLC1/NECL-2 triggers NK-cell and CD8+ T-cell responses through the cell-surface receptor CRTAM.49
266949682016CRTAM determines the CD4+ cytotoxic T lymphocyte lineage.36
220516972012Genome-wide association study reveals class I MHC-restricted T cell-associated molecule gene (CRTAM) variants interact with vitamin D levels to affect asthma exacerbations.14
205567942010CRTAM: A molecule involved in epithelial cell adhesion.7
238273832013A genome-wide association study for malignant mesothelioma risk.7
196957072009Characterization of CRTAM gene promoter: AP-1 transcription factor control its expression in human T CD8 lymphocytes.4
238714862013Competition of cell adhesion and immune recognition: insights into the interaction between CRTAM and nectin-like 2.4
259109592015CRTAM is negatively regulated by ZEB1 in T cells.3
235301482013CRTAM receptor engagement by Necl-2 on tumor cells triggers cell death of activated Vγ9Vδ2 T cells.2

Citation

Dessen P

CRTAM (cytotoxic and regulatory T cell molecule)

Atlas Genet Cytogenet Oncol Haematol. 2007-02-01

Online version: http://atlasgeneticsoncology.org/gene/45934/crtam-(cytotoxic-and-regulatory-t-cell-molecule)