DUOXA2 (dual oxidase maturation factor 2)

2007-02-01  

Identity

HGNC
LOCATION
15q21.1
LOCUSID
ALIAS
SIMNIPHOM,TDH5

Other Information

Locus ID:

NCBI: 405753
MIM: 612772
HGNC: 32698
Ensembl: ENSG00000140274

Variants:

dbSNP: 405753
ClinVar: 405753
TCGA: ENSG00000140274
COSMIC: DUOXA2

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000140274ENST00000323030Q1HG44
ENSG00000140274ENST00000491993Q1HG44

Expression (GTEx)

0
5
10
15
20
25
30

Pathways

PathwaySourceExternal ID
Thyroid hormone synthesisKEGGhsa04918
Thyroid hormone synthesisKEGGko04918

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
166512682006Identification of the maturation factor for dual oxidase. Evolution of an eukaryotic operon equivalent.103
173748492007Missense mutations of dual oxidase 2 (DUOX2) implicated in congenital hypothyroidism have impaired trafficking in cells reconstituted with DUOX2 maturation factor.31
213211102011Up-regulation and sustained activation of Stat1 are essential for interferon-gamma (IFN-gamma)-induced dual oxidase 2 (Duox2) and dual oxidase A2 (DuoxA2) expression in human pancreatic cancer cell lines.30
244923132014DUOX2 and DUOXA2 form the predominant enzyme system capable of producing the reactive oxygen species H2O2 in active ulcerative colitis and are modulated by 5-aminosalicylic acid.28
193395562009Heterodimerization controls localization of Duox-DuoxA NADPH oxidases in airway cells.27
230104982013Thyroid hydrogen peroxide production is enhanced by the Th2 cytokines, IL-4 and IL-13, through increased expression of the dual oxidase 2 and its maturation factor DUOXA2.11
228142542012The type of DUOX-dependent ROS production is dictated by defined sequences in DUOXA.10
257619042015When an Intramolecular Disulfide Bridge Governs the Interaction of DUOX2 with Its Partner DUOXA2.8
187000072008Five mucosal transcripts of interest in ulcerative colitis identified by quantitative real-time PCR: a prospective study.4
225929222012Dual oxidase 2 bidirectional promoter polymorphisms confer differential immune responses in airway epithelia.2

Citation

Dessen P

DUOXA2 (dual oxidase maturation factor 2)

Atlas Genet Cytogenet Oncol Haematol. 2007-02-01

Online version: http://atlasgeneticsoncology.org/gene/45935/duoxa2-(dual-oxidase-maturation-factor-2)