SLC38A3 (solute carrier family 38 member 3)

2007-02-01  

Identity

HGNC
SLC38A3
LOCATION
3p21.31
LOCUSID
10991
ALIAS
G17,NAT1,SN1,SNAT3
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 10991
MIM: 604437
HGNC: 18044
Ensembl: ENSG00000188338

Variants:

dbSNP: 10991
ClinVar: 10991
TCGA: ENSG00000188338
COSMIC: SLC38A3

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000188338ENST00000445096A0A087WWS5
ENSG00000188338ENST00000610458A0A087WVW8
ENSG00000188338ENST00000614032Q99624
ENSG00000188338ENST00000621456A0A087X1Q4
ENSG00000188338ENST00000621714A0A087X175

Expression (GTEx)

0
50
100
150
200
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Proximal tubule bicarbonate reclamationKEGGko04964
Proximal tubule bicarbonate reclamationKEGGhsa04964
Glutamatergic synapseKEGGko04724
Glutamatergic synapseKEGGhsa04724
GABAergic synapseKEGGko04727
GABAergic synapseKEGGhsa04727
Transmembrane transport of small moleculesREACTOMER-HSA-382551
SLC-mediated transmembrane transportREACTOMER-HSA-425407
Transport of inorganic cations/anions and amino acids/oligopeptidesREACTOMER-HSA-425393
Amino acid transport across the plasma membraneREACTOMER-HSA-352230

References

Pubmed IDYearTitleCitations
383096152024Glutamine transporter SLC38A3 promotes breast cancer metastasis via Gsk3β/β-catenin/EMT pathway.2
383096152024Glutamine transporter SLC38A3 promotes breast cancer metastasis via Gsk3β/β-catenin/EMT pathway.2
346058552022Biallelic variants in SLC38A3 encoding a glutamine transporter cause epileptic encephalopathy.11
346058552022Biallelic variants in SLC38A3 encoding a glutamine transporter cause epileptic encephalopathy.11
282023522017Amino acid transporter SLC38A3 promotes metastasis of non-small cell lung cancer cells by activating PDK1.23
282023522017Amino acid transporter SLC38A3 promotes metastasis of non-small cell lung cancer cells by activating PDK1.23
248548472014Expression of glutamine transporter Slc38a3 (SNAT3) during acidosis is mediated by a different mechanism than tissue-specific expression.7
248548472014Expression of glutamine transporter Slc38a3 (SNAT3) during acidosis is mediated by a different mechanism than tissue-specific expression.7
198924002009Expression and role of SNAT3 in the placenta.1
198924002009Expression and role of SNAT3 in the placenta.1
164328332006Down regulation of 3p genes, LTF, SLC38A3 and DRR1, upon growth of human chromosome 3-mouse fibrosarcoma hybrids in severe combined immunodeficiency mice.22
164328332006Down regulation of 3p genes, LTF, SLC38A3 and DRR1, upon growth of human chromosome 3-mouse fibrosarcoma hybrids in severe combined immunodeficiency mice.22
150944552004Increased expression of a glutamine transporter SNAT3 is a marker of malignant gliomas.21
150944552004Increased expression of a glutamine transporter SNAT3 is a marker of malignant gliomas.21
127880822003Properties and regulation of glutamine transporter SN1 by protein kinases SGK and PKB.17

Citation

Dessen P

SLC38A3 (solute carrier family 38 member 3)

Atlas Genet Cytogenet Oncol Haematol. 2007-02-01

Online version: http://atlasgeneticsoncology.org/gene/45952/slc38a3-(solute-carrier-family-38-member-3)