FUT6 (fucosyltransferase 6)

2007-02-01  

Identity

HGNC
FUT6
LOCATION
19p13.3
LOCUSID
2528
ALIAS
FCT3A,FT1A,Fuc-TVI,FucT-VI

Other Information

Locus ID:

NCBI: 2528
MIM: 136836
HGNC: 4017
Ensembl: ENSG00000156413

Variants:

dbSNP: 2528
ClinVar: 2528
TCGA: ENSG00000156413
COSMIC: FUT6

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000156413ENST00000286955P51993
ENSG00000156413ENST00000318336P51993
ENSG00000156413ENST00000524754P51993
ENSG00000156413ENST00000527106P51993
ENSG00000156413ENST00000528505E9PJB4
ENSG00000156413ENST00000531085E9PS22
ENSG00000156413ENST00000531199E9PP56
ENSG00000156413ENST00000532464E9PJ18
ENSG00000156413ENST00000592563P51993

Expression (GTEx)

0
10
20
30
40
50
60
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Glycosphingolipid biosynthesis - lacto and neolacto seriesKEGGko00601
Glycosphingolipid biosynthesis - lacto and neolacto seriesKEGGhsa00601
Metabolic pathwaysKEGGhsa01100

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
361513322023FUT6 inhibits the proliferation, migration, invasion, and EGF-induced EMT of head and neck squamous cell carcinoma (HNSCC) by regulating EGFR/ERK/STAT signaling pathway.6
361513322023FUT6 inhibits the proliferation, migration, invasion, and EGF-induced EMT of head and neck squamous cell carcinoma (HNSCC) by regulating EGFR/ERK/STAT signaling pathway.6
342158302021FUT6 deficiency compromises basophil function by selectively abrogating their sialyl-Lewis x expression.5
342158302021FUT6 deficiency compromises basophil function by selectively abrogating their sialyl-Lewis x expression.5
329014862020Using Eukaryotic Expression Systems to Generate Human α1,3-Fucosyltransferases That Effectively Create Selectin-Binding Glycans on Stem Cells.3
329014862020Using Eukaryotic Expression Systems to Generate Human α1,3-Fucosyltransferases That Effectively Create Selectin-Binding Glycans on Stem Cells.3
303074992019Whole genome sequence association with E-selectin levels reveals loss-of-function variant in African Americans.10
307429322019HOTAIR/miR-326/FUT6 axis facilitates colorectal cancer progression through regulating fucosylation of CD44 via PI3K/AKT/mTOR pathway.37
308085442019Overexpressed N-fucosylation on the cell surface driven by FUT3, 5, and 6 promotes cell motilities in metastatic pancreatic cancer cell lines.7
303074992019Whole genome sequence association with E-selectin levels reveals loss-of-function variant in African Americans.10
307429322019HOTAIR/miR-326/FUT6 axis facilitates colorectal cancer progression through regulating fucosylation of CD44 via PI3K/AKT/mTOR pathway.37
308085442019Overexpressed N-fucosylation on the cell surface driven by FUT3, 5, and 6 promotes cell motilities in metastatic pancreatic cancer cell lines.7
283347922017GWAS identifies population-specific new regulatory variants in FUT6 associated with plasma B12 concentrations in Indians.17
287712242017miR-125a-3p/FUT5-FUT6 axis mediates colorectal cancer cell proliferation, migration, invasion and pathological angiogenesis via PI3K-Akt pathway.61
283347922017GWAS identifies population-specific new regulatory variants in FUT6 associated with plasma B12 concentrations in Indians.17

Citation

Dessen P

FUT6 (fucosyltransferase 6)

Atlas Genet Cytogenet Oncol Haematol. 2007-02-01

Online version: http://atlasgeneticsoncology.org/gene/45954/fut6-(fucosyltransferase-6)