EAF2 (ELL associated factor 2)

2007-02-01 Affiliation

Identity

HGNC

EAF2

LOCATION

3q13.33

LOCUSID

55840

ALIAS

BM040,TRAITS,U19

FUSION GENES

Show Gene Fusions

Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool

Other Information

Locus ID:

NCBI: 55840
MIM: 607659
HGNC: 23115
Ensembl: ENSG00000145088

Variants:

dbSNP: 55840
ClinVar: 55840
TCGA: ENSG00000145088
COSMIC: EAF2

RNA/Proteins

Gene ID	Transcript ID	Uniprot
ENSG00000145088	ENST00000273668	Q96CJ1
ENSG00000145088	ENST00000451944	B4DWJ3
ENSG00000145088	ENST00000490434	F8WCI9
ENSG00000145088	ENST00000490477	F8WF04

Expression (GTEx)

Adipose - Subcutaneous

Adipose - Visceral

Adrenal Gland

Artery - Aorta

Artery - Tibial

Bladder

Brain - Amygdala

Brain - Anterior cingulate cortex

Brain - Caudate

Brain - Cerebellar Hemisphere

Brain - Cerebellum

Brain - Cortex

Brain - Frontal Cortex

Brain - Hippocampus

Brain - Hypothalamus

Brain - Nucleus accumbens

Brain - Putamen

Brain - Spinal cord

Brain - Substantia nigra

Breast - Mammary Tissue

Cells - Cultured fibroblasts

Cells - EBV - transformed lymphocytes

Cervix - Ectocervix

Cervix - Endocervix

Colon - Sigmoid

Colon - Transverse

Esophagus - Gastroesophageal Junction

Esophagus - Mucosa

Esophagus - Muscularis

Fallopian Tube

Heart - Atrial Appendage

Heart - Left Ventricle

Kidney - Cortex

Kidney - Medulla

Liver

Lung

Minor Salivary Gland

Muscle - Skeletal

Nerve - Tibial

Ovary

Pancreas

Pituitary

Prostate

Skin - Not Sun Exposed

Skin - Sun Exposed

Small Intestine - Terminal Ileum

Spleen

Stomach

Testis

Thyroid

Uterus

Vagina

Whole Blood

Pathways

Pathway	Source	External ID
Gene Expression	REACTOME	R-HSA-74160
RNA Polymerase II Transcription	REACTOME	R-HSA-73857
RNA Polymerase II Pre-transcription Events	REACTOME	R-HSA-674695
RNA Polymerase II Transcription Elongation	REACTOME	R-HSA-75955
Formation of RNA Pol II elongation complex	REACTOME	R-HSA-112382

Protein levels (Protein atlas)

Not detected

Low

Medium

High

References

Pubmed ID	Year	Title	Citations
37426316	2023	Mechanism of ELL-associated factor 2 and vasohibin 1 regulating invasion, migration, and angiogenesis in colorectal cancer.	1
37426316	2023	Mechanism of ELL-associated factor 2 and vasohibin 1 regulating invasion, migration, and angiogenesis in colorectal cancer.	1
34852843	2021	CircEAF2 counteracts Epstein-Barr virus-positive diffuse large B-cell lymphoma progression via miR-BART19-3p/APC/β-catenin axis.	11
34852843	2021	CircEAF2 counteracts Epstein-Barr virus-positive diffuse large B-cell lymphoma progression via miR-BART19-3p/APC/β-catenin axis.	11
33182068	2020	Systematic expression analysis of EAF family reveals the importance of EAF2 in melanoma.	2
33182068	2020	Systematic expression analysis of EAF family reveals the importance of EAF2 in melanoma.	2
30088132	2019	Candidate Tumor Suppressor Gene EAF2 is Mutated in Colorectal and Gastric Cancers.	3
30088132	2019	Candidate Tumor Suppressor Gene EAF2 is Mutated in Colorectal and Gastric Cancers.	3
29257273	2018	Eaf2 protects human lens epithelial cells against oxidative stress‑induced apoptosis by Wnt signaling.	7
29518696	2018	EAF2 and p53 Co-Regulate STAT3 Activation in Prostate Cancer.	13
30009504	2018	Regulation of ELL2 stability and polyubiquitination by EAF2 in prostate cancer cells.	6
29257273	2018	Eaf2 protects human lens epithelial cells against oxidative stress‑induced apoptosis by Wnt signaling.	7
29518696	2018	EAF2 and p53 Co-Regulate STAT3 Activation in Prostate Cancer.	13
30009504	2018	Regulation of ELL2 stability and polyubiquitination by EAF2 in prostate cancer cells.	6
27721405	2017	EAF2 regulates DNA repair through Ku70/Ku80 in the prostate.	14

Citation

Dessen P

EAF2 (ELL associated factor 2)

Atlas Genet Cytogenet Oncol Haematol. 2007-02-01

Online version: http://atlasgeneticsoncology.org/gene/45970/eaf2-(ell-associated-factor-2)