TLR8 (toll like receptor 8)

2007-02-01  

Identity

HGNC
TLR8
LOCATION
Xp22.2
LOCUSID
51311
ALIAS
CD288

Other Information

Locus ID:

NCBI: 51311
MIM: 300366
HGNC: 15632
Ensembl: ENSG00000101916

Variants:

dbSNP: 51311
ClinVar: 51311
TCGA: ENSG00000101916
COSMIC: TLR8

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000101916ENST00000218032Q9NR97
ENSG00000101916ENST00000311912Q9NR97

Expression (GTEx)

0
5
10
15
20
25
30
35
40
45
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Toll-like receptor signaling pathwayKEGGko04620
Toll-like receptor signaling pathwayKEGGhsa04620
Immune SystemREACTOMER-HSA-168256
Innate Immune SystemREACTOMER-HSA-168249
Toll-Like Receptors CascadesREACTOMER-HSA-168898
Trafficking and processing of endosomal TLRREACTOMER-HSA-1679131
Toll Like Receptor 7/8 (TLR7/8) CascadeREACTOMER-HSA-168181
MyD88 dependent cascade initiated on endosomeREACTOMER-HSA-975155
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activationREACTOMER-HSA-975138
TRAF6 mediated IRF7 activation in TLR7/8 or 9 signalingREACTOMER-HSA-975110
Toll Like Receptor 9 (TLR9) CascadeREACTOMER-HSA-168138

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
376657472024TLR8 aggravates skin inflammation and fibrosis by activating skin fibroblasts in systemic sclerosis.0
386318422024TLR8-activating miR-146a-3p is an intermediate signal contributing to fetal membrane inflammation in response to bacterial LPS.0
389718582024Erythroid-intrinsic activation of TLR8 impairs erythropoiesis in inherited anemia.0
376657472024TLR8 aggravates skin inflammation and fibrosis by activating skin fibroblasts in systemic sclerosis.0
386318422024TLR8-activating miR-146a-3p is an intermediate signal contributing to fetal membrane inflammation in response to bacterial LPS.0
389718582024Erythroid-intrinsic activation of TLR8 impairs erythropoiesis in inherited anemia.0
362717732023Toll-like receptors 3, 7, 8, and 9 in gastric cancer.0
365859092023TLR8 agonist partially improves IFN-γ deficiency of NK cells in chronic hepatitis B through the synergy of monocytes.0
371995632023Long non-coding RNA TLR8-AS1 induces preeclampsia through increasing TLR8/STAT1 axis.1
373954412023CD8 T Cell-Derived Exosomal miR-186-5p Elicits Renal Inflammation via Activating Tubular TLR7/8 Signal Axis.4
374513202023Human toll-like receptor 8 (TLR8) in NK cells: Implication for cancer immunotherapy.1
374953962023Human TLR8 induces inflammatory bone marrow erythromyeloblastic islands and anemia in SLE-prone mice.2
377235012023TLR8 escapes X chromosome inactivation in human monocytes and CD4(+) T cells.4
362717732023Toll-like receptors 3, 7, 8, and 9 in gastric cancer.0
365859092023TLR8 agonist partially improves IFN-γ deficiency of NK cells in chronic hepatitis B through the synergy of monocytes.0

Citation

Dessen P

TLR8 (toll like receptor 8)

Atlas Genet Cytogenet Oncol Haematol. 2007-02-01

Online version: http://atlasgeneticsoncology.org/gene/45973/tlr8-(toll-like-receptor-8)