PRSS3 (serine protease 3)

2007-02-01  

Identity

HGNC
PRSS3
LOCATION
9p13.3
LOCUSID
5646
ALIAS
MTG,PRSS4,T9,TRY3,TRY4
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 5646
MIM: 613578
HGNC: 9486
Ensembl: ENSG00000010438

Variants:

dbSNP: 5646
ClinVar: 5646
TCGA: ENSG00000010438
COSMIC: PRSS3

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000010438ENST00000342836P35030
ENSG00000010438ENST00000361005P35030
ENSG00000010438ENST00000379405P35030
ENSG00000010438ENST00000429677P35030
ENSG00000010438ENST00000457896B1AN99

Expression (GTEx)

0
500
1000
1500
2000
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Neuroactive ligand-receptor interactionKEGGko04080
Neuroactive ligand-receptor interactionKEGGhsa04080
Pancreatic secretionKEGGko04972
Pancreatic secretionKEGGhsa04972
Protein digestion and absorptionKEGGko04974
Protein digestion and absorptionKEGGhsa04974
Influenza AKEGGko05164
Influenza AKEGGhsa05164
Immune SystemREACTOMER-HSA-168256
Innate Immune SystemREACTOMER-HSA-168249
DefensinsREACTOMER-HSA-1461973
Alpha-defensinsREACTOMER-HSA-1462054
MetabolismREACTOMER-HSA-1430728
Metabolism of vitamins and cofactorsREACTOMER-HSA-196854
Metabolism of water-soluble vitamins and cofactorsREACTOMER-HSA-196849
Cobalamin (Cbl, vitamin B12) transport and metabolismREACTOMER-HSA-196741
Antimicrobial peptidesREACTOMER-HSA-6803157
Neutrophil degranulationREACTOMER-HSA-6798695

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
373956512023Shear Stress Drives the Cleavage Activation of Protease-Activated Receptor 2 by PRSS3/Mesotrypsin to Promote Invasion and Metastasis of Circulating Lung Cancer Cells.1
373956512023Shear Stress Drives the Cleavage Activation of Protease-Activated Receptor 2 by PRSS3/Mesotrypsin to Promote Invasion and Metastasis of Circulating Lung Cancer Cells.1
358966022022Host neuronal PRSS3 interacts with enterovirus A71 3A protein and its role in viral replication.5
366189652022Serine Protease 3 Promotes Progression of Diffuse Large B-Cell Lymphoma and Serves as a Novel Prognostic Predictor.1
358966022022Host neuronal PRSS3 interacts with enterovirus A71 3A protein and its role in viral replication.5
366189652022Serine Protease 3 Promotes Progression of Diffuse Large B-Cell Lymphoma and Serves as a Novel Prognostic Predictor.1
335155472021Defective binding of SPINK1 variants is an uncommon mechanism for impaired trypsin inhibition in chronic pancreatitis.13
337581422021High Expression of PRSS3 Indicates Unfavorable Clinical Outcomes in Colon Adenocarcinoma.4
341956832021In-depth proteomics analysis of sentinel lymph nodes from individuals with endometrial cancer.17
335155472021Defective binding of SPINK1 variants is an uncommon mechanism for impaired trypsin inhibition in chronic pancreatitis.13
337581422021High Expression of PRSS3 Indicates Unfavorable Clinical Outcomes in Colon Adenocarcinoma.4
341956832021In-depth proteomics analysis of sentinel lymph nodes from individuals with endometrial cancer.17
319119422020PRSS contributes to cetuximab resistance in colorectal cancer.17
320149972020Inactivation of mesotrypsin by chymotrypsin C prevents trypsin inhibitor degradation.7
319119422020PRSS contributes to cetuximab resistance in colorectal cancer.17

Citation

Dessen P

PRSS3 (serine protease 3)

Atlas Genet Cytogenet Oncol Haematol. 2007-02-01

Online version: http://atlasgeneticsoncology.org/gene/45981/js/lib/humanGenome