NKD2 (NKD inhibitor of WNT signaling pathway 2)

2007-02-01  

Identity

HGNC
NKD2
LOCATION
5p15.33
LOCUSID
85409
ALIAS
Naked2
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 85409
MIM: 607852
HGNC: 17046
Ensembl: ENSG00000145506

Variants:

dbSNP: 85409
ClinVar: 85409
TCGA: ENSG00000145506
COSMIC: NKD2

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000145506ENST00000274150Q969F2
ENSG00000145506ENST00000296849Q969F2

Expression (GTEx)

0
10
20
30
40
50
60
70
80
90
100
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Wnt signaling pathwayKEGGko04310
Wnt signaling pathwayKEGGhsa04310

Protein levels (Protein atlas)

Not detected
Low
Medium
High
N/A

References

Pubmed IDYearTitleCitations
368209512023NKD2 Trigger NF-κB Signaling Pathway and Facilitates Thyroid Cancer Cell Proliferation.1
368209512023NKD2 Trigger NF-κB Signaling Pathway and Facilitates Thyroid Cancer Cell Proliferation.1
330453172021LINC00922 regulates epithelial-mesenchymal transition, invasive and migratory capacities in breast cancer through promoting NKD2 methylation.18
344330252021NKD2 mediates stimulation-dependent ORAI1 trafficking to augment Ca(2+) entry in T cells.2
330453172021LINC00922 regulates epithelial-mesenchymal transition, invasive and migratory capacities in breast cancer through promoting NKD2 methylation.18
344330252021NKD2 mediates stimulation-dependent ORAI1 trafficking to augment Ca(2+) entry in T cells.2
309418532019Protein kinase A-mediated phosphorylation of naked cuticle homolog 2 stimulates cell-surface delivery of transforming growth factor-α for epidermal growth factor receptor transactivation.5
309418532019Protein kinase A-mediated phosphorylation of naked cuticle homolog 2 stimulates cell-surface delivery of transforming growth factor-α for epidermal growth factor receptor transactivation.5
291268342018Low expression of NKD2 is associated with enhanced cell proliferation and poor prognosis in human hepatocellular carcinoma.4
296788992018ZFAS1 functions as an oncogenic long non-coding RNA in bladder cancer.17
291268342018Low expression of NKD2 is associated with enhanced cell proliferation and poor prognosis in human hepatocellular carcinoma.4
296788992018ZFAS1 functions as an oncogenic long non-coding RNA in bladder cancer.17
272469762017Long noncoding RNA ZFAS1 promotes gastric cancer cells proliferation by epigenetically repressing KLF2 and NKD2 expression.82
272469762017Long noncoding RNA ZFAS1 promotes gastric cancer cells proliferation by epigenetically repressing KLF2 and NKD2 expression.82
269021202016miR-130b targets NKD2 and regulates the Wnt signaling to promote proliferation and inhibit apoptosis in osteosarcoma cells.16

Citation

Dessen P

NKD2 (NKD inhibitor of WNT signaling pathway 2)

Atlas Genet Cytogenet Oncol Haematol. 2007-02-01

Online version: http://atlasgeneticsoncology.org/gene/45982/nkd2-(nkd-inhibitor-of-wnt-signaling-pathway-2)