REN (renin)

2007-02-01  

Identity

HGNC
LOCATION
1q32.1
LOCUSID
ALIAS
ADTKD4,HNFJ2,RTD
FUSION GENES

Other Information

Locus ID:

NCBI: 5972
MIM: 179820
HGNC: 9958
Ensembl: ENSG00000143839

Variants:

dbSNP: 5972
ClinVar: 5972
TCGA: ENSG00000143839
COSMIC: REN

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000143839ENST00000272190P00797
ENSG00000143839ENST00000638118A0A1B0GUZ2

Expression (GTEx)

0
5
10
15
20
25
30
35
40
45
50

Pathways

PathwaySourceExternal ID
Renin-angiotensin systemKEGGko04614
Renin-angiotensin systemKEGGhsa04614
Renin secretionKEGGhsa04924
Renin secretionKEGGko04924
Metabolism of proteinsREACTOMER-HSA-392499
Peptide hormone metabolismREACTOMER-HSA-2980736
Metabolism of Angiotensinogen to AngiotensinsREACTOMER-HSA-2022377

Protein levels (Protein atlas)

Not detected
Low
Medium
High

PharmGKB

Entity IDNameTypeEvidenceAssociationPKPDPMIDs
PA162356187muraglitazarChemicalClinicalAnnotationassociatedPD18794727
PA443886Diabetes MellitusDiseaseClinicalAnnotationassociatedPD18794727
PA443994EdemaDiseaseClinicalAnnotationassociatedPD18794727
PA444528HyperlipidemiasDiseaseClinicalAnnotationassociatedPD18794727

References

Pubmed IDYearTitleCitations
120452552002Pivotal role of the renin/prorenin receptor in angiotensin II production and cellular responses to renin.344
185198262008Molecular genetics of successful smoking cessation: convergent genome-wide association study results.130
199131212009Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip.85
220428112011Gene expression profiling reveals renin mRNA overexpression in human hypertensive kidneys and a role for microRNAs.72
203796142010Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.62
182122692008Prorenin and renin-induced extracellular signal-regulated kinase 1/2 activation in monocytes is not blocked by aliskiren or the handle-region peptide.57
169402152006Prorenin induces intracellular signaling in cardiomyocytes independently of angiotensin II.53
150751922004Increased blood pressure in transgenic mice expressing both human renin and angiotensinogen in the renal proximal tubule.50
202019262010Human variation in alcohol response is influenced by variation in neuronal signaling genes.45
196647452009Dominant renin gene mutations associated with early-onset hyperuricemia, anemia, and chronic kidney failure.36

Citation

Dessen P

REN (renin)

Atlas Genet Cytogenet Oncol Haematol. 2007-02-01

Online version: http://atlasgeneticsoncology.org/gene/45987/ren-(renin)