ACSL3 (acyl-CoA synthetase long chain family member 3)

2007-02-01  

Identity

HGNC
LOCATION
2q36.1
LOCUSID
ALIAS
ACS3,FACL3,LACS
FUSION GENES

Other Information

Locus ID:

NCBI: 2181
MIM: 602371
HGNC: 3570
Ensembl: ENSG00000123983

Variants:

dbSNP: 2181
ClinVar: 2181
TCGA: ENSG00000123983
COSMIC: ACSL3

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000123983ENST00000357430O95573
ENSG00000123983ENST00000357430A0A024R497
ENSG00000123983ENST00000392066O95573
ENSG00000123983ENST00000392066A0A024R497
ENSG00000123983ENST00000407441H7BYZ7
ENSG00000123983ENST00000413316C9JC11
ENSG00000123983ENST00000535678F5H062
ENSG00000123983ENST00000540115F5GWH2

Expression (GTEx)

0
10
20
30
40
50
60

Pathways

PathwaySourceExternal ID
Fatty acid biosynthesisKEGGko00061
Fatty acid degradationKEGGko00071
PPAR signaling pathwayKEGGko03320
Adipocytokine signaling pathwayKEGGko04920
Fatty acid biosynthesisKEGGhsa00061
Fatty acid degradationKEGGhsa00071
PPAR signaling pathwayKEGGhsa03320
Adipocytokine signaling pathwayKEGGhsa04920
PeroxisomeKEGGko04146
PeroxisomeKEGGhsa04146
Metabolic pathwaysKEGGhsa01100
beta-Oxidation, acyl-CoA synthesisKEGGhsa_M00086
beta-Oxidation, acyl-CoA synthesisKEGGM00086
Fatty acid metabolismKEGGhsa01212
Fatty acid metabolismKEGGko01212
MetabolismREACTOMER-HSA-1430728
Metabolism of lipids and lipoproteinsREACTOMER-HSA-556833
Fatty acid, triacylglycerol, and ketone body metabolismREACTOMER-HSA-535734
Triglyceride BiosynthesisREACTOMER-HSA-75109
Fatty Acyl-CoA BiosynthesisREACTOMER-HSA-75105
Synthesis of very long-chain fatty acyl-CoAsREACTOMER-HSA-75876
FerroptosisKEGGko04216
FerroptosisKEGGhsa04216

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
192216032009Relation of DNA methylation of 5'-CpG island of ACSL3 to transplacental exposure to airborne polycyclic aromatic hydrocarbons and childhood asthma.132
223577062012The N-terminal region of acyl-CoA synthetase 3 is essential for both the localization on lipid droplets and the function in fatty acid uptake.44
180036212008Long chain acyl-CoA synthetase 3-mediated phosphatidylcholine synthesis is required for assembly of very low density lipoproteins in human hepatoma Huh7 cells.38
274772802016Fatty Acid Oxidation Mediated by Acyl-CoA Synthetase Long Chain 3 Is Required for Mutant KRAS Lung Tumorigenesis.35
179015422007The fatty acid transport protein (FATP) family: very long chain acyl-CoA synthetases or solute carriers?29
213284612011ACSL3 and GSK-3β are essential for lipid upregulation induced by endoplasmic reticulum stress in liver cells.22
177619452007Transcriptional activation of hepatic ACSL3 and ACSL5 by oncostatin m reduces hypertriglyceridemia through enhanced beta-oxidation.20
203080792010Long chain acyl-CoA synthetase-3 is a molecular target for peroxisome proliferator-activated receptor delta in HepG2 hepatoma cells.19
238408322013Palmitic acid induces osteoblastic differentiation in vascular smooth muscle cells through ACSL3 and NF-κB, novel targets of eicosapentaenoic acid.18
202199002010Activation of LXR increases acyl-CoA synthetase activity through direct regulation of ACSL3 in human placental trophoblast cells.15

Citation

Dessen P

ACSL3 (acyl-CoA synthetase long chain family member 3)

Atlas Genet Cytogenet Oncol Haematol. 2007-02-01

Online version: http://atlasgeneticsoncology.org/gene/45991/acsl3-(acyl-coa-synthetase-long-chain-family-member-3)