M6PR (mannose-6-phosphate receptor, cation dependent)

2007-02-01  

Identity

HGNC
LOCATION
12p13.31
LOCUSID
ALIAS
CD-M6PR,CD-MPR,MPR

Other Information

Locus ID:

NCBI: 4074
MIM: 154540
HGNC: 6752
Ensembl: ENSG00000003056

Variants:

dbSNP: 4074
ClinVar: 4074
TCGA: ENSG00000003056
COSMIC: M6PR

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000003056ENST00000000412P20645
ENSG00000003056ENST00000536844F5GX30
ENSG00000003056ENST00000537621H0YGT2
ENSG00000003056ENST00000539143H0YFL0
ENSG00000003056ENST00000541507F5H883
ENSG00000003056ENST00000543159F5GXE0
ENSG00000003056ENST00000543258H0YGE9
ENSG00000003056ENST00000543704H0YF90
ENSG00000003056ENST00000543845F5GXU0
ENSG00000003056ENST00000544193H0YFY9
ENSG00000003056ENST00000544245F5H4U1

Expression (GTEx)

0
50
100
150

Pathways

PathwaySourceExternal ID
LysosomeKEGGko04142
LysosomeKEGGhsa04142
PhagosomeKEGGko04145
PhagosomeKEGGhsa04145
Vesicle-mediated transportREACTOMER-HSA-5653656
Membrane TraffickingREACTOMER-HSA-199991
trans-Golgi Network Vesicle BuddingREACTOMER-HSA-199992
Clathrin derived vesicle buddingREACTOMER-HSA-421837
Lysosome Vesicle BiogenesisREACTOMER-HSA-432720
Intra-Golgi and retrograde Golgi-to-ER trafficREACTOMER-HSA-6811442
Retrograde transport at the Trans-Golgi-NetworkREACTOMER-HSA-6811440
Clathrin-mediated endocytosisREACTOMER-HSA-8856828
Cargo recognition for clathrin-mediated endocytosisREACTOMER-HSA-8856825

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
364843892023Gimap5 promoted RSV degradation through interaction with M6PR.0
374004402023Loss of the batten disease protein CLN3 leads to mis-trafficking of M6PR and defective autophagic-lysosomal reformation.7
364843892023Gimap5 promoted RSV degradation through interaction with M6PR.0
374004402023Loss of the batten disease protein CLN3 leads to mis-trafficking of M6PR and defective autophagic-lysosomal reformation.7
346888182022Association between genetic variants in oxidative stress-related genes and osteoporotic bone fracture. The Hortega follow-up study.3
346888182022Association between genetic variants in oxidative stress-related genes and osteoporotic bone fracture. The Hortega follow-up study.3
342447812021Golgi-58K can re-localize to late endosomes upon cellular uptake of PS-ASOs and facilitates endosomal release of ASOs.5
342447812021Golgi-58K can re-localize to late endosomes upon cellular uptake of PS-ASOs and facilitates endosomal release of ASOs.5
318401802020Golgi-endosome transport mediated by M6PR facilitates release of antisense oligonucleotides from endosomes.22
324376662020Monochorionic twins with selective fetal growth restriction: insight from placental whole-transcriptome analysis.1
318401802020Golgi-endosome transport mediated by M6PR facilitates release of antisense oligonucleotides from endosomes.22
324376662020Monochorionic twins with selective fetal growth restriction: insight from placental whole-transcriptome analysis.1
292751032018Most rotavirus strains require the cation-independent mannose-6-phosphate receptor, sortilin-1, and cathepsins to enter cells.7
297696592018Mannose-6-phosphate receptor: a novel regulator of T cell immunity.8
300861592018Cation-dependent mannose-6-phosphate receptor expression and distribution are influenced by estradiol in MCF-7 breast cancer cells.9

Citation

Dessen P

M6PR (mannose-6-phosphate receptor, cation dependent)

Atlas Genet Cytogenet Oncol Haematol. 2007-02-01

Online version: http://atlasgeneticsoncology.org/gene/46022/m6pr