CPB2 (carboxypeptidase B2)

2007-02-01  

Identity

HGNC
LOCATION
13q14.13
LOCUSID
ALIAS
CPU,PCPB,TAFI
FUSION GENES

Other Information

Locus ID:

NCBI: 1361
MIM: 603101
HGNC: 2300
Ensembl: ENSG00000080618

Variants:

dbSNP: 1361
ClinVar: 1361
TCGA: ENSG00000080618
COSMIC: CPB2

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000080618ENST00000181383Q96IY4
ENSG00000080618ENST00000439329A0A087WSY5

Expression (GTEx)

0
50
100
150
200
250
300
350
400
450

Pathways

PathwaySourceExternal ID
Complement and coagulation cascadesKEGGko04610
Complement and coagulation cascadesKEGGhsa04610
Pancreatic secretionKEGGko04972
Pancreatic secretionKEGGhsa04972
Protein digestion and absorptionKEGGko04974
Protein digestion and absorptionKEGGhsa04974
Metabolism of proteinsREACTOMER-HSA-392499
Peptide hormone metabolismREACTOMER-HSA-2980736
Metabolism of Angiotensinogen to AngiotensinsREACTOMER-HSA-2022377

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
199131212009Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip.85
203796142010Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.62
145259952003Thrombin activatable fibrinolysis inhibitor, a potential regulator of vascular inflammation.49
203857902010Venous thrombosis risk associated with plasma hypofibrinolysis is explained by elevated plasma levels of TAFI and PAI-1.49
189748422008Gender differences in genetic risk profiles for cardiovascular disease.33
190107842009Regulation of chemerin bioactivity by plasma carboxypeptidase N, carboxypeptidase B (activated thrombin-activable fibrinolysis inhibitor), and platelets.28
218041932011Plasma carboxypeptidase B downregulates inflammatory responses in autoimmune arthritis.21
173888012007TAFIa, PAI-1 and alpha-antiplasmin: complementary roles in regulating lysis of thrombi and plasma clots.20
120064042002Plasma thrombin-activatable fibrinolysis inhibitor antigen concentration and genotype in relation to myocardial infarction in the north and south of Europe.18
128300062003Deficiency of thrombin activatable fibrinolysis inhibitor in cirrhosis is associated with increased plasma fibrinolysis.18

Citation

Dessen P

CPB2 (carboxypeptidase B2)

Atlas Genet Cytogenet Oncol Haematol. 2007-02-01

Online version: http://atlasgeneticsoncology.org/gene/46024/cpb2-(carboxypeptidase-b2)