CD80 (CD80 molecule)

2007-02-01  

Identity

HGNC
LOCATION
3q13.33
LOCUSID
ALIAS
B7,B7-1,B7.1,BB1,CD28LG,CD28LG1,LAB7

Other Information

Locus ID:

NCBI: 941
MIM: 112203
HGNC: 1700
Ensembl: ENSG00000121594

Variants:

dbSNP: 941
ClinVar: 941
TCGA: ENSG00000121594
COSMIC: CD80

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000121594ENST00000264246P33681
ENSG00000121594ENST00000264246A0N0P2
ENSG00000121594ENST00000383669P33681
ENSG00000121594ENST00000478182P33681
ENSG00000121594ENST00000478182A0N0P2

Expression (GTEx)

0
10
20
30
40
50
60
70
80

Pathways

PathwaySourceExternal ID
Cell adhesion molecules (CAMs)KEGGko04514
Toll-like receptor signaling pathwayKEGGko04620
Type I diabetes mellitusKEGGko04940
Autoimmune thyroid diseaseKEGGko05320
Systemic lupus erythematosusKEGGko05322
Allograft rejectionKEGGko05330
Graft-versus-host diseaseKEGGko05332
Cell adhesion molecules (CAMs)KEGGhsa04514
Toll-like receptor signaling pathwayKEGGhsa04620
Type I diabetes mellitusKEGGhsa04940
Autoimmune thyroid diseaseKEGGhsa05320
Systemic lupus erythematosusKEGGhsa05322
Allograft rejectionKEGGhsa05330
Graft-versus-host diseaseKEGGhsa05332
Viral myocarditisKEGGhsa05416
Intestinal immune network for IgA productionKEGGko04672
Intestinal immune network for IgA productionKEGGhsa04672
Rheumatoid arthritisKEGGko05323
Rheumatoid arthritisKEGGhsa05323
DiseaseREACTOMER-HSA-1643685
Diseases of signal transductionREACTOMER-HSA-5663202
PI3K/AKT Signaling in CancerREACTOMER-HSA-2219528
Constitutive Signaling by Aberrant PI3K in CancerREACTOMER-HSA-2219530
Immune SystemREACTOMER-HSA-168256
Adaptive Immune SystemREACTOMER-HSA-1280218
Costimulation by the CD28 familyREACTOMER-HSA-388841
CD28 co-stimulationREACTOMER-HSA-389356
CD28 dependent PI3K/Akt signalingREACTOMER-HSA-389357
CD28 dependent Vav1 pathwayREACTOMER-HSA-389359
CTLA4 inhibitory signalingREACTOMER-HSA-389513
Signaling by the B Cell Receptor (BCR)REACTOMER-HSA-983705
Downstream signaling events of B Cell Receptor (BCR)REACTOMER-HSA-1168372
PIP3 activates AKT signalingREACTOMER-HSA-1257604
Negative regulation of the PI3K/AKT networkREACTOMER-HSA-199418
Innate Immune SystemREACTOMER-HSA-168249
DAP12 interactionsREACTOMER-HSA-2172127
DAP12 signalingREACTOMER-HSA-2424491
Fc epsilon receptor (FCERI) signalingREACTOMER-HSA-2454202
Role of LAT2/NTAL/LAB on calcium mobilizationREACTOMER-HSA-2730905
Cytokine Signaling in Immune systemREACTOMER-HSA-1280215
Signaling by InterleukinsREACTOMER-HSA-449147
Signal TransductionREACTOMER-HSA-162582
Signaling by EGFRREACTOMER-HSA-177929
GAB1 signalosomeREACTOMER-HSA-180292
Signalling by NGFREACTOMER-HSA-166520
NGF signalling via TRKA from the plasma membraneREACTOMER-HSA-187037
PI3K/AKT activationREACTOMER-HSA-198203
Signaling by PDGFREACTOMER-HSA-186797
Downstream signal transductionREACTOMER-HSA-186763
Signaling by SCF-KITREACTOMER-HSA-1433557
PI5P, PP2A and IER3 Regulate PI3K/AKT SignalingREACTOMER-HSA-6811558
Interleukin-10 signalingREACTOMER-HSA-6783783

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
376140912024Clinicopathologic Evaluation of CD80, CD86, and PD-L1 Expressions with Immunohistochemical Methods in Malignant Melanoma Patients.0
376140912024Clinicopathologic Evaluation of CD80, CD86, and PD-L1 Expressions with Immunohistochemical Methods in Malignant Melanoma Patients.0
350220892023Expression and Prognostic Value of CD80 and CD86 in the Tumor Microenvironment of Newly Diagnosed Glioblastoma.2
350220892023Expression and Prognostic Value of CD80 and CD86 in the Tumor Microenvironment of Newly Diagnosed Glioblastoma.2
347387072022Clinicopathological significance of CD28 overexpression in adult T-cell leukemia/lymphoma.6
360644212022The role of soluble CD80 in patients with soft tissue tumors.3
361076352022Human immunomodulatory ligand B7-1 mediates synaptic remodeling via the p75 neurotrophin receptor.3
347387072022Clinicopathological significance of CD28 overexpression in adult T-cell leukemia/lymphoma.6
360644212022The role of soluble CD80 in patients with soft tissue tumors.3
361076352022Human immunomodulatory ligand B7-1 mediates synaptic remodeling via the p75 neurotrophin receptor.3
333584552021Predicting the functional consequences of genetic variants in co-stimulatory ligand B7-1 using in-silico approaches.0
335060282021CD80 Insights as Therapeutic Target in the Current and Future Treatment Options of Frequent-Relapse Minimal Change Disease.2
338687912021CD80 expression is upregulated by TP53 activation in human cancer epithelial cells.12
341913842021Cryptic association of B7-2 molecules and its implication for clustering.2
333584552021Predicting the functional consequences of genetic variants in co-stimulatory ligand B7-1 using in-silico approaches.0

Citation

Dessen P

CD80 (CD80 molecule)

Atlas Genet Cytogenet Oncol Haematol. 2007-02-01

Online version: http://atlasgeneticsoncology.org/gene/46034/cd80-(cd80-molecule)