RBPJ (recombination signal binding protein for immunoglobulin kappa J region)

2007-02-01  

Identity

HGNC
LOCATION
4p15.2
LOCUSID
ALIAS
AOS3,CBF-1,CBF1,IGKJRB,IGKJRB1,KBF2,RBP-J,RBP-J
FUSION GENES

Other Information

Locus ID:

NCBI: 3516
MIM: 147183
HGNC: 5724
Ensembl: ENSG00000168214

Variants:

dbSNP: 3516
ClinVar: 3516
TCGA: ENSG00000168214
COSMIC: RBPJ

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000168214ENST00000342295Q06330
ENSG00000168214ENST00000342320Q06330
ENSG00000168214ENST00000345843Q06330
ENSG00000168214ENST00000348160Q06330
ENSG00000168214ENST00000355476Q06330
ENSG00000168214ENST00000361572Q06330
ENSG00000168214ENST00000504423H0Y8R3
ENSG00000168214ENST00000504907D6R927
ENSG00000168214ENST00000504938D6RB37
ENSG00000168214ENST00000505958D6RE93
ENSG00000168214ENST00000506956D6RIZ8
ENSG00000168214ENST00000507561Q06330
ENSG00000168214ENST00000507574D6RBQ8
ENSG00000168214ENST00000509158D6RF98
ENSG00000168214ENST00000510778D6RCM1
ENSG00000168214ENST00000511546D6R9X3
ENSG00000168214ENST00000512351D6RAT2
ENSG00000168214ENST00000512671D6R946
ENSG00000168214ENST00000513182D6RIV8
ENSG00000168214ENST00000514675D6R9K5
ENSG00000168214ENST00000514730D6REC2
ENSG00000168214ENST00000514807D6REP3
ENSG00000168214ENST00000515573D6RA45

Expression (GTEx)

0
10
20
30
40
50
60

Pathways

PathwaySourceExternal ID
Notch signaling pathwayKEGGko04330
Notch signaling pathwayKEGGhsa04330
Epstein-Barr virus infectionKEGGhsa05169
Epstein-Barr virus infectionKEGGko05169
Viral carcinogenesisKEGGhsa05203
Viral carcinogenesisKEGGko05203
Notch signalingKEGGhsa_M00682
Notch signalingKEGGM00682
DiseaseREACTOMER-HSA-1643685
Diseases of signal transductionREACTOMER-HSA-5663202
Signaling by NOTCH1 in CancerREACTOMER-HSA-2644603
Signaling by NOTCH1 PEST Domain Mutants in CancerREACTOMER-HSA-2644602
Constitutive Signaling by NOTCH1 PEST Domain MutantsREACTOMER-HSA-2644606
Signaling by NOTCH1 HD+PEST Domain Mutants in CancerREACTOMER-HSA-2894858
Constitutive Signaling by NOTCH1 HD+PEST Domain MutantsREACTOMER-HSA-2894862
Signal TransductionREACTOMER-HSA-162582
Signaling by NOTCHREACTOMER-HSA-157118
Pre-NOTCH Expression and ProcessingREACTOMER-HSA-1912422
Pre-NOTCH Transcription and TranslationREACTOMER-HSA-1912408
Signaling by NOTCH1REACTOMER-HSA-1980143
NOTCH1 Intracellular Domain Regulates TranscriptionREACTOMER-HSA-2122947
Signaling by NOTCH2REACTOMER-HSA-1980145
NOTCH2 intracellular domain regulates transcriptionREACTOMER-HSA-2197563
Gene ExpressionREACTOMER-HSA-74160
Generic Transcription PathwayREACTOMER-HSA-212436
Notch-HLH transcription pathwayREACTOMER-HSA-350054
Developmental BiologyREACTOMER-HSA-1266738
Regulation of beta-cell developmentREACTOMER-HSA-186712
Regulation of gene expression in late stage (branching morphogenesis) pancreatic bud precursor cellsREACTOMER-HSA-210744
Th1 and Th2 cell differentiationKEGGko04658
Th1 and Th2 cell differentiationKEGGhsa04658

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
362083722023Hsa_circ_0001535 Regulates Colorectal Cancer Progression via the miR-433-3p/RBPJ Axis.0
370519082023Rbpj Deficiency Disrupts Vascular Remodeling via Abnormal Apelin and Cdc42 (Cell Division Cycle 42) Activity in Brain Arteriovenous Malformation.2
377565412023Jagged1 Acts as an RBP-J Target and Feedback Suppresses TNF-Mediated Inflammatory Osteoclastogenesis.0
362083722023Hsa_circ_0001535 Regulates Colorectal Cancer Progression via the miR-433-3p/RBPJ Axis.0
370519082023Rbpj Deficiency Disrupts Vascular Remodeling via Abnormal Apelin and Cdc42 (Cell Division Cycle 42) Activity in Brain Arteriovenous Malformation.2
377565412023Jagged1 Acts as an RBP-J Target and Feedback Suppresses TNF-Mediated Inflammatory Osteoclastogenesis.0
358447852022Interaction between BEND5 and RBPJ suppresses breast cancer growth and metastasis via inhibiting Notch signaling.1
364773672022The structure, binding and function of a Notch transcription complex involving RBPJ and the epigenetic reader protein L3MBTL3.1
358447852022Interaction between BEND5 and RBPJ suppresses breast cancer growth and metastasis via inhibiting Notch signaling.1
364773672022The structure, binding and function of a Notch transcription complex involving RBPJ and the epigenetic reader protein L3MBTL3.1
330340232021Transcription Factor RBPJ as a Molecular Switch in Regulating the Notch Response.22
333115522021Merkel cell carcinoma-derived exosome-shuttle miR-375 induces fibroblast polarization by inhibition of RBPJ and p53.19
333874512021Ageing promotes early T follicular helper cell differentiation by modulating expression of RBPJ.12
333892832021LncRNA FTX Promotes Colorectal Cancer Cells Migration and Invasion by miRNA-590-5p/RBPJ Axis.15
346552782021Colon cancer cells secreted CXCL11 via RBP-Jκ to facilitated tumour-associated macrophage-induced cancer metastasis.13

Citation

Dessen P

RBPJ (recombination signal binding protein for immunoglobulin kappa J region)

Atlas Genet Cytogenet Oncol Haematol. 2007-02-01

Online version: http://atlasgeneticsoncology.org/gene/46041/rbpj-(recombination-signal-binding-protein-for-immunoglobulin-kappa-j-region)