KIF1B (kinesin family member 1B)

2007-02-01  

Identity

HGNC
KIF1B
LOCATION
1p36.22
LOCUSID
23095
ALIAS
CMT2,CMT2A,CMT2A1,HMSNII,KLP,NBLST1
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 23095
MIM: 605995
HGNC: 16636
Ensembl: ENSG00000054523

Variants:

dbSNP: 23095
ClinVar: 23095
TCGA: ENSG00000054523
COSMIC: KIF1B

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000054523ENST00000263934O60333
ENSG00000054523ENST00000377081O60333
ENSG00000054523ENST00000377083O60333
ENSG00000054523ENST00000377086O60333
ENSG00000054523ENST00000377093O60333
ENSG00000054523ENST00000620295Q4R9M9
ENSG00000054523ENST00000622724A0A087WWA3
ENSG00000054523ENST00000635499A0A0U1RQL3

Expression (GTEx)

0
50
100
150
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
HemostasisREACTOMER-HSA-109582
Factors involved in megakaryocyte development and platelet productionREACTOMER-HSA-983231
KinesinsREACTOMER-HSA-983189
Vesicle-mediated transportREACTOMER-HSA-5653656
Membrane TraffickingREACTOMER-HSA-199991
Intra-Golgi and retrograde Golgi-to-ER trafficREACTOMER-HSA-6811442
Golgi-to-ER retrograde transportREACTOMER-HSA-8856688
COPI-dependent Golgi-to-ER retrograde trafficREACTOMER-HSA-6811434

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
341121672021USP9X promotes apoptosis in cholangiocarcinoma by modulation expression of KIF1Bβ via deubiquitinating EGLN3.7
341121672021USP9X promotes apoptosis in cholangiocarcinoma by modulation expression of KIF1Bβ via deubiquitinating EGLN3.7
333970432020Whole Exome Sequencing Identifies Novel Genetic Alterations in Patients with Pheochromocytoma/Paraganglioma.8
333970432020Whole Exome Sequencing Identifies Novel Genetic Alterations in Patients with Pheochromocytoma/Paraganglioma.8
308596322019Tumor suppressor KIF1Bβ regulates mitochondrial apoptosis in collaboration with YME1L1.11
309476872019Association between KIF1B rs17401966 genetic polymorphism and hepatocellular carcinoma susceptibility: an updated meta-analysis.4
315410152019FIGNL1 associates with KIF1Bβ and BICD1 to restrict dynein transport velocity during axon navigation.2
319349892019[Associations of single nucleotide polymorphisms of KIF1B gene with the severity of clinical manifestations of multiple sclerosis].0
308596322019Tumor suppressor KIF1Bβ regulates mitochondrial apoptosis in collaboration with YME1L1.11
309476872019Association between KIF1B rs17401966 genetic polymorphism and hepatocellular carcinoma susceptibility: an updated meta-analysis.4
315410152019FIGNL1 associates with KIF1Bβ and BICD1 to restrict dynein transport velocity during axon navigation.2
319349892019[Associations of single nucleotide polymorphisms of KIF1B gene with the severity of clinical manifestations of multiple sclerosis].0
284272532017Meta-analysis of the correlation between the rs17401966 polymorphism in kinesin family member 1B and susceptibility to hepatitis B virus related hepatocellular carcinoma.3
285150462017KIF1B and NF1 are the most frequently mutated genes in paraganglioma and pheochromocytoma tumors.11
284272532017Meta-analysis of the correlation between the rs17401966 polymorphism in kinesin family member 1B and susceptibility to hepatitis B virus related hepatocellular carcinoma.3

Citation

Dessen P

KIF1B (kinesin family member 1B)

Atlas Genet Cytogenet Oncol Haematol. 2007-02-01

Online version: http://atlasgeneticsoncology.org/gene/46043/kif1b-(kinesin-family-member-1b)