Identity
HGNC
LOCATION
12q21.1
LOCUSID
ALIAS
FEX,GPR49,GPR67,GRP49,HG38
FUSION GENES
Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool
Other Information
Locus ID:
NCBI: 8549
MIM: 606667
HGNC: 4504
Ensembl: ENSG00000139292
Variants:
dbSNP: 8549
ClinVar: 8549
TCGA: ENSG00000139292
COSMIC: LGR5
RNA/Proteins
| Gene ID | Transcript ID | Uniprot |
|---|---|---|
| ENSG00000139292 | ENST00000266674 | O75473 |
| ENSG00000139292 | ENST00000266674 | A0A0A8K8C7 |
| ENSG00000139292 | ENST00000536515 | O75473 |
| ENSG00000139292 | ENST00000540815 | O75473 |
Expression (GTEx)
Pathways
Protein levels (Protein atlas)
PharmGKB
| Entity ID | Name | Type | Evidence | Association | PK | PD | PMIDs |
|---|---|---|---|---|---|---|---|
| PA128406956 | fluorouracil | Chemical | ClinicalAnnotation | associated | PD | 25665511 | |
| PA443756 | Colonic Neoplasms | Disease | ClinicalAnnotation | associated | PD | 25665511 |
References
| Pubmed ID | Year | Title | Citations |
|---|---|---|---|
| 36318235 | 2023 | Elevated Expression of LGR5 and WNT Signaling Factors in Neuroblastoma Cells With Acquired Drug Resistance. | 4 |
| 36833408 | 2023 | TCF7L1 Regulates LGR5 Expression in Colorectal Cancer Cells. | 2 |
| 36853294 | 2023 | Evaluation of LGR5 Cancer Stem Cell Marker Expression in Breast Cancer and Its Relationship with Hormonal Profile and Clinical Pathological Features. | 2 |
| 37453564 | 2023 | Genome-Wide Association Study Identifies 4 Novel Risk Loci for Small Intestinal Neuroendocrine Tumors Including a Missense Mutation in LGR5. | 1 |
| 37512045 | 2023 | The Expression of Stem Cell Marker LGR5 and Its Coexpression with Β-Catenin in Sporadic Colorectal Carcinoma and Adenoma: A Comparative Immunohistochemical Study. | 1 |
| 37548329 | 2023 | Detecting rare thalassemia in children with anemia using third-generation sequencing. | 0 |
| 36318235 | 2023 | Elevated Expression of LGR5 and WNT Signaling Factors in Neuroblastoma Cells With Acquired Drug Resistance. | 4 |
| 36833408 | 2023 | TCF7L1 Regulates LGR5 Expression in Colorectal Cancer Cells. | 2 |
| 36853294 | 2023 | Evaluation of LGR5 Cancer Stem Cell Marker Expression in Breast Cancer and Its Relationship with Hormonal Profile and Clinical Pathological Features. | 2 |
| 37453564 | 2023 | Genome-Wide Association Study Identifies 4 Novel Risk Loci for Small Intestinal Neuroendocrine Tumors Including a Missense Mutation in LGR5. | 1 |
| 37512045 | 2023 | The Expression of Stem Cell Marker LGR5 and Its Coexpression with Β-Catenin in Sporadic Colorectal Carcinoma and Adenoma: A Comparative Immunohistochemical Study. | 1 |
| 37548329 | 2023 | Detecting rare thalassemia in children with anemia using third-generation sequencing. | 0 |
| 34494239 | 2022 | Protruding structures with high expression of LGR5 are formed during regrowth phase after chemo-treatment in xenograft model of colorectal adenocarcinoma. | 0 |
| 34657081 | 2022 | Prognostic Impact of LGR5, Prox1, and Notch1 Biomarkers in Stage II to III Colon Cancer. | 3 |
| 35123536 | 2022 | LGR5 expression and clinicopathological features of the invasive front in the fat infiltration area of pancreatic cancer. | 4 |
Citation
Dessen P
LGR5 (leucine rich repeat containing G protein-coupled receptor 5)
Atlas Genet Cytogenet Oncol Haematol. 2007-02-01
Online version: http://atlasgeneticsoncology.org/gene/46044/lgr5-(leucine-rich-repeat-containing-g-protein-coupled-receptor-5)
