LGR5 (leucine rich repeat containing G protein-coupled receptor 5)

2007-02-01  

Identity

HGNC
LOCATION
12q21.1
LOCUSID
ALIAS
FEX,GPR49,GPR67,GRP49,HG38
FUSION GENES

Other Information

Locus ID:

NCBI: 8549
MIM: 606667
HGNC: 4504
Ensembl: ENSG00000139292

Variants:

dbSNP: 8549
ClinVar: 8549
TCGA: ENSG00000139292
COSMIC: LGR5

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000139292ENST00000266674O75473
ENSG00000139292ENST00000266674A0A0A8K8C7
ENSG00000139292ENST00000536515O75473
ENSG00000139292ENST00000540815O75473

Expression (GTEx)

0
5
10
15
20

Pathways

PathwaySourceExternal ID
Signal TransductionREACTOMER-HSA-162582
Signaling by WntREACTOMER-HSA-195721
TCF dependent signaling in response to WNTREACTOMER-HSA-201681
Regulation of FZD by ubiquitinationREACTOMER-HSA-4641263

Protein levels (Protein atlas)

Not detected
Low
Medium
High

PharmGKB

Entity IDNameTypeEvidenceAssociationPKPDPMIDs
PA128406956fluorouracilChemicalClinicalAnnotationassociatedPD25665511
PA443756Colonic NeoplasmsDiseaseClinicalAnnotationassociatedPD25665511

References

Pubmed IDYearTitleCitations
179344492007Identification of stem cells in small intestine and colon by marker gene Lgr5.1769
183729032008Meta-analysis of genome-wide association data and large-scale replication identifies additional susceptibility loci for type 2 diabetes.829
190203232008Genotype score in addition to common risk factors for prediction of type 2 diabetes.304
216936462011R-spondins function as ligands of the orphan receptors LGR4 and LGR5 to regulate Wnt/beta-catenin signaling.276
190203242008Clinical risk factors, DNA variants, and the development of type 2 diabetes.262
185913882008Assessing the combined impact of 18 common genetic variants of modest effect sizes on type 2 diabetes risk.129
191970022009Wnt signaling, lgr5, and stem cells in the intestine and skin.112
229690422012Monoclonal antibodies against Lgr5 identify human colorectal cancer stem cells.83
229999372012Lgr5(+ve) stem/progenitor cells contribute to nephron formation during kidney development.79
165752082006Identification of overexpression of orphan G protein-coupled receptor GPR49 in human colon and ovarian primary tumors.76

Citation

Dessen P

LGR5 (leucine rich repeat containing G protein-coupled receptor 5)

Atlas Genet Cytogenet Oncol Haematol. 2007-02-01

Online version: http://atlasgeneticsoncology.org/gene/46044/lgr5-(leucine-rich-repeat-containing-g-protein-coupled-receptor-5)