HHEX (hematopoietically expressed homeobox)

2007-02-01  

Identity

HGNC
HHEX
LOCATION
10q23.33
LOCUSID
3087
ALIAS
HEX,HMPH,HOX11L-PEN,PRH,PRHX
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 3087
MIM: 604420
HGNC: 4901
Ensembl: ENSG00000152804

Variants:

dbSNP: 3087
ClinVar: 3087
TCGA: ENSG00000152804
COSMIC: HHEX

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000152804ENST00000282728Q03014
ENSG00000152804ENST00000472590F8VU08
ENSG00000152804ENST00000492654F8VU08

Expression (GTEx)

0
50
100
150
200
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Maturity onset diabetes of the youngKEGGko04950
Maturity onset diabetes of the youngKEGGhsa04950
Transcriptional misregulation in cancerKEGGko05202
Transcriptional misregulation in cancerKEGGhsa05202

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
371036012023Association of HHEX and SLC30A8 Gene Polymorphisms with Gestational Diabetes Mellitus Susceptibility: A Meta-analysis.4
372482642023Elucidation of HHEX in pancreatic endoderm differentiation using a human iPSC differentiation model.2
373025182023HHEX suppresses advanced thyroid cancer by interacting with TLE3.3
371036012023Association of HHEX and SLC30A8 Gene Polymorphisms with Gestational Diabetes Mellitus Susceptibility: A Meta-analysis.4
372482642023Elucidation of HHEX in pancreatic endoderm differentiation using a human iPSC differentiation model.2
373025182023HHEX suppresses advanced thyroid cancer by interacting with TLE3.3
358872982022Unraveling the Influence of HHEX Risk Polymorphism rs7923837 on Multiple Sclerosis Pathogenesis.1
360084112022CK2-induced cooperation of HHEX with the YAP-TEAD4 complex promotes colorectal tumorigenesis.9
358872982022Unraveling the Influence of HHEX Risk Polymorphism rs7923837 on Multiple Sclerosis Pathogenesis.1
360084112022CK2-induced cooperation of HHEX with the YAP-TEAD4 complex promotes colorectal tumorigenesis.9
343210412021Hhex inhibits cell migration via regulating RHOA/CDC42-CFL1 axis in human lung cancer cells.6
346239012021Integrated single-cell transcriptomics and epigenomics reveals strong germinal center-associated etiology of autoimmune risk loci.10
343210412021Hhex inhibits cell migration via regulating RHOA/CDC42-CFL1 axis in human lung cancer cells.6
346239012021Integrated single-cell transcriptomics and epigenomics reveals strong germinal center-associated etiology of autoimmune risk loci.10
318439822020A Runaway PRH/HHEX-Notch3-Positive Feedback Loop Drives Cholangiocarcinoma and Determines Response to CDK4/6 Inhibition.12

Citation

Dessen P

HHEX (hematopoietically expressed homeobox)

Atlas Genet Cytogenet Oncol Haematol. 2007-02-01

Online version: http://atlasgeneticsoncology.org/gene/46061/hhex-(hematopoietically-expressed-homeobox)