IFNGR2 (interferon gamma receptor 2)

2007-02-01 Affiliation

Identity

HGNC

IFNGR2

LOCATION

21q22.11

LOCUSID

3460

ALIAS

AF-1,IFGR2,IFNGT1,IMD28

FUSION GENES

Show Gene Fusions

Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool

Other Information

Locus ID:

NCBI: 3460
MIM: 147569
HGNC: 5440
Ensembl: ENSG00000159128

Variants:

dbSNP: 3460
ClinVar: 3460
TCGA: ENSG00000159128
COSMIC: IFNGR2

RNA/Proteins

Gene ID	Transcript ID	Uniprot
ENSG00000159128	ENST00000290219	P38484
ENSG00000159128	ENST00000290219	A8K881
ENSG00000159128	ENST00000381995	E7EUY1
ENSG00000159128	ENST00000405436	B5MCZ0
ENSG00000159128	ENST00000421802	H7C1V5
ENSG00000159128	ENST00000439213	F8WF11
ENSG00000159128	ENST00000545369	F8WE34

Expression (GTEx)

100

150

Adipose - Subcutaneous

Adipose - Visceral

Adrenal Gland

Artery - Aorta

Artery - Tibial

Bladder

Brain - Amygdala

Brain - Anterior cingulate cortex

Brain - Caudate

Brain - Cerebellar Hemisphere

Brain - Cerebellum

Brain - Cortex

Brain - Frontal Cortex

Brain - Hippocampus

Brain - Hypothalamus

Brain - Nucleus accumbens

Brain - Putamen

Brain - Spinal cord

Brain - Substantia nigra

Breast - Mammary Tissue

Cells - Cultured fibroblasts

Cells - EBV - transformed lymphocytes

Cervix - Ectocervix

Cervix - Endocervix

Colon - Sigmoid

Colon - Transverse

Esophagus - Gastroesophageal Junction

Esophagus - Mucosa

Esophagus - Muscularis

Fallopian Tube

Heart - Atrial Appendage

Heart - Left Ventricle

Kidney - Cortex

Kidney - Medulla

Liver

Lung

Minor Salivary Gland

Muscle - Skeletal

Nerve - Tibial

Ovary

Pancreas

Pituitary

Prostate

Skin - Not Sun Exposed

Skin - Sun Exposed

Small Intestine - Terminal Ileum

Spleen

Stomach

Testis

Thyroid

Uterus

Vagina

Whole Blood

Pathways

Pathway	Source	External ID
Cytokine-cytokine receptor interaction	KEGG	ko04060
Jak-STAT signaling pathway	KEGG	ko04630
Natural killer cell mediated cytotoxicity	KEGG	ko04650
Cytokine-cytokine receptor interaction	KEGG	hsa04060
Jak-STAT signaling pathway	KEGG	hsa04630
Natural killer cell mediated cytotoxicity	KEGG	hsa04650
Leishmaniasis	KEGG	ko05140
Leishmaniasis	KEGG	hsa05140
Chagas disease (American trypanosomiasis)	KEGG	ko05142
Chagas disease (American trypanosomiasis)	KEGG	hsa05142
Toxoplasmosis	KEGG	ko05145
Toxoplasmosis	KEGG	hsa05145
Osteoclast differentiation	KEGG	ko04380
Osteoclast differentiation	KEGG	hsa04380
Measles	KEGG	ko05162
Measles	KEGG	hsa05162
Tuberculosis	KEGG	ko05152
Tuberculosis	KEGG	hsa05152
Influenza A	KEGG	ko05164
Influenza A	KEGG	hsa05164
Salmonella infection	KEGG	ko05132
Salmonella infection	KEGG	hsa05132
Herpes simplex infection	KEGG	ko05168
Herpes simplex infection	KEGG	hsa05168
HIF-1 signaling pathway	KEGG	hsa04066
Inflammatory bowel disease (IBD)	KEGG	hsa05321
Inflammatory bowel disease (IBD)	KEGG	ko05321
Immune System	REACTOME	R-HSA-168256
Cytokine Signaling in Immune system	REACTOME	R-HSA-1280215
Interferon Signaling	REACTOME	R-HSA-913531
Interferon gamma signaling	REACTOME	R-HSA-877300
Regulation of IFNG signaling	REACTOME	R-HSA-877312
Th1 and Th2 cell differentiation	KEGG	ko04658
Th1 and Th2 cell differentiation	KEGG	hsa04658
Th17 cell differentiation	KEGG	ko04659
Th17 cell differentiation	KEGG	hsa04659

Protein levels (Protein atlas)

Not detected

Low

Medium

High

References

Pubmed ID	Year	Title	Citations
36639711	2023	CircIFNGR2 enhances proliferation and migration of CRC and induces cetuximab resistance by indirectly targeting KRAS via sponging to MiR-30b.	5
36639711	2023	CircIFNGR2 enhances proliferation and migration of CRC and induces cetuximab resistance by indirectly targeting KRAS via sponging to MiR-30b.	5
33260695	2020	Susceptibility to Heart Defects in Down Syndrome Is Associated with Single Nucleotide Polymorphisms in HAS 21 Interferon Receptor Cluster and VEGFA Genes.	8
33260695	2020	Susceptibility to Heart Defects in Down Syndrome Is Associated with Single Nucleotide Polymorphisms in HAS 21 Interferon Receptor Cluster and VEGFA Genes.	8
31222290	2018	A purely quantitative form of partial recessive IFN-γR2 deficiency caused by mutations of the initiation or second codon.	9
31222290	2018	A purely quantitative form of partial recessive IFN-γR2 deficiency caused by mutations of the initiation or second codon.	9
27563937	2017	IFNGR2 genetic polymorphism associated with sex-specific paranoid schizophrenia risk.	6
28652404	2017	Current prospects of type II interferon γ signaling and autoimmunity.	76
29106381	2017	A digenic human immunodeficiency characterized by IFNAR1 and IFNGR2 mutations.	37
29434065	2017	Identification of a single nucleotide polymorphism indicative of high risk in acute myocardial infarction.	3
27563937	2017	IFNGR2 genetic polymorphism associated with sex-specific paranoid schizophrenia risk.	6
28652404	2017	Current prospects of type II interferon γ signaling and autoimmunity.	76
29106381	2017	A digenic human immunodeficiency characterized by IFNAR1 and IFNGR2 mutations.	37
29434065	2017	Identification of a single nucleotide polymorphism indicative of high risk in acute myocardial infarction.	3
27499022	2016	Glycosylation-Dependent IFN-γR Partitioning in Lipid and Actin Nanodomains Is Critical for JAK Activation.	57

Citation

Dessen P

IFNGR2 (interferon gamma receptor 2)

Atlas Genet Cytogenet Oncol Haematol. 2007-02-01

Online version: http://atlasgeneticsoncology.org/gene/46082/ifngr2-(interferon-gamma-receptor-2)