OCLN (occludin)

2007-02-01  

Identity

HGNC
LOCATION
5q13.2
LOCUSID
ALIAS
BLCPMG,PPP1R115,PTORCH1
FUSION GENES

Other Information

Locus ID:

NCBI: 100506658
MIM: 602876
HGNC: 8104
Ensembl: ENSG00000197822

Variants:

dbSNP: 100506658
ClinVar: 100506658
TCGA: ENSG00000197822
COSMIC: OCLN

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000197822ENST00000355237Q16625
ENSG00000197822ENST00000396442Q16625
ENSG00000197822ENST00000538151Q16625

Expression (GTEx)

0
5
10
15

Pathways

PathwaySourceExternal ID
Cell adhesion molecules (CAMs)KEGGko04514
Tight junctionKEGGko04530
Leukocyte transendothelial migrationKEGGko04670
Pathogenic Escherichia coli infectionKEGGko05130
Cell adhesion molecules (CAMs)KEGGhsa04514
Tight junctionKEGGhsa04530
Leukocyte transendothelial migrationKEGGhsa04670
Pathogenic Escherichia coli infectionKEGGhsa05130
Hepatitis CKEGGko05160
Hepatitis CKEGGhsa05160
Programmed Cell DeathREACTOMER-HSA-5357801
ApoptosisREACTOMER-HSA-109581
Apoptotic execution phaseREACTOMER-HSA-75153
Apoptotic cleavage of cellular proteinsREACTOMER-HSA-111465
Apoptotic cleavage of cell adhesion proteinsREACTOMER-HSA-351906

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
377213322024Association of serum occludin levels and perihematomal edema volumes in intracranial hemorrhage patients.2
381411132024Occludin is overexpressed in tubo-ovarian high-grade serous carcinoma compared to mesothelioma and is a marker of tumor progression and chemoresistance.0
377213322024Association of serum occludin levels and perihematomal edema volumes in intracranial hemorrhage patients.2
381411132024Occludin is overexpressed in tubo-ovarian high-grade serous carcinoma compared to mesothelioma and is a marker of tumor progression and chemoresistance.0
365361832023The role of mir-197-3p in regulating the tight junction permeability of celiac disease patients under gluten free diet.1
366621632023Serum claudin-5, claudin-11, occludin, vinculin, paxillin, and beta-catenin levels in preschool children with autism spectrum disorder.5
367682872023Does the Blood-Brain Barrier Integrity Change in Regard to the Onset of Fetal Growth Restriction?1
369460502023[Porphyromonas gingivalis infection causes umbilical vein endothelial barrier dysfunction in vitro by down-regulating ZO-1, occludin and VE-cadherin expression].1
370682482023Tight junction protein occludin is an internalization factor for SARS-CoV-2 infection and mediates virus cell-to-cell transmission.4
372728422023Hepatitis C Virus Disrupts Annexin 5-Mediated Occludin Integrity through Downregulation of Protein Kinase Cα (PKCα) and PKCη Expression, Thereby Promoting Viral Propagation.0
381573662023Roles of epidermal growth factor receptor, claudin-1 and occludin in multi-step entry of hepatitis C virus into polarized hepatoma spheroids.0
365361832023The role of mir-197-3p in regulating the tight junction permeability of celiac disease patients under gluten free diet.1
366621632023Serum claudin-5, claudin-11, occludin, vinculin, paxillin, and beta-catenin levels in preschool children with autism spectrum disorder.5
367682872023Does the Blood-Brain Barrier Integrity Change in Regard to the Onset of Fetal Growth Restriction?1
369460502023[Porphyromonas gingivalis infection causes umbilical vein endothelial barrier dysfunction in vitro by down-regulating ZO-1, occludin and VE-cadherin expression].1

Citation

Dessen P

OCLN (occludin)

Atlas Genet Cytogenet Oncol Haematol. 2007-02-01

Online version: http://atlasgeneticsoncology.org/gene/46084/ocln-(occludin)