ATP12A (ATPase H+/K+ transporting non-gastric alpha2 subunit)

2007-02-01  

Identity

HGNC
LOCATION
13q12.12
LOCUSID
ALIAS
ATP1AL1,H-K-ATPase,HK
FUSION GENES

Other Information

Locus ID:

NCBI: 479
MIM: 182360
HGNC: 13816
Ensembl: ENSG00000075673

Variants:

dbSNP: 479
ClinVar: 479
TCGA: ENSG00000075673
COSMIC: ATP12A

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000075673ENST00000218548P54707
ENSG00000075673ENST00000381946P54707

Expression (GTEx)

0
1
2
3
4
5

Pathways

PathwaySourceExternal ID
Oxidative phosphorylationKEGGko00190
Oxidative phosphorylationKEGGhsa00190
Transmembrane transport of small moleculesREACTOMER-HSA-382551
Ion channel transportREACTOMER-HSA-983712
Ion transport by P-type ATPasesREACTOMER-HSA-936837

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
268234282016Airway acidification initiates host defense abnormalities in cystic fibrosis mice.93
203796142010Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.62
196944092009A C-terminal lobe of the beta subunit of Na,K-ATPase and H,K-ATPase resembles cell adhesion molecules.8
118802792002Nongastric H-K-ATPase in rodent prostate: lobe-specific expression and apical localization.7
293914512018ATP12A promotes mucus dysfunction during Type 2 airway inflammation.6
121105182002Stimulation of protein kinase C pathway mediates endocytosis of human nongastric H+-K+-ATPase, ATP1AL1.5
303333102018Increased expression of ATP12A proton pump in cystic fibrosis airways.5
151352332004Non-gastric H+/K+ ATPase is present in the microvillous membrane of the human placental syncytiotrophoblast.3
221790162011Expression of the non-gastric H+/K+ ATPase ATP12A in normal and pathological human prostate tissue.3
122308092002Expression of ATP1AL1, a non-gastric proton pump, in human colorectum.2

Citation

Dessen P

ATP12A (ATPase H+/K+ transporting non-gastric alpha2 subunit)

Atlas Genet Cytogenet Oncol Haematol. 2007-02-01

Online version: http://atlasgeneticsoncology.org/gene/46088/atp12a-(atpase-h+-k+-transporting-non-gastric-alpha2-subunit)