NT5C2 (5-nucleotidase, cytosolic II)

2007-02-01 Affiliation

Identity

HGNC

NT5C2

LOCATION

10q24.32

LOCUSID

22978

ALIAS

GMP,NT5B,PNT5,SPG45,SPG65,cN-II

FUSION GENES

Show Gene Fusions

Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool

Other Information

Locus ID:

NCBI: 22978
MIM: 600417
HGNC: 8022
Ensembl: ENSG00000076685

Variants:

dbSNP: 22978
ClinVar: 22978
TCGA: ENSG00000076685
COSMIC: NT5C2

RNA/Proteins

Gene ID	Transcript ID	Uniprot
ENSG00000076685	ENST00000343289	P49902
ENSG00000076685	ENST00000343289	A0A384MED8
ENSG00000076685	ENST00000404739	P49902
ENSG00000076685	ENST00000404739	A0A384MED8
ENSG00000076685	ENST00000421281	Q5JUV6
ENSG00000076685	ENST00000452156	Q5JUV4
ENSG00000076685	ENST00000458345	Q5JUV3
ENSG00000076685	ENST00000461461	S4R3A6
ENSG00000076685	ENST00000470299	S4R3E7
ENSG00000076685	ENST00000552185	H0YHR8

Expression (GTEx)

Adipose - Subcutaneous

Adipose - Visceral

Adrenal Gland

Artery - Aorta

Artery - Tibial

Bladder

Brain - Amygdala

Brain - Anterior cingulate cortex

Brain - Caudate

Brain - Cerebellar Hemisphere

Brain - Cerebellum

Brain - Cortex

Brain - Frontal Cortex

Brain - Hippocampus

Brain - Hypothalamus

Brain - Nucleus accumbens

Brain - Putamen

Brain - Spinal cord

Brain - Substantia nigra

Breast - Mammary Tissue

Cells - Cultured fibroblasts

Cells - EBV - transformed lymphocytes

Cervix - Ectocervix

Cervix - Endocervix

Colon - Sigmoid

Colon - Transverse

Esophagus - Gastroesophageal Junction

Esophagus - Mucosa

Esophagus - Muscularis

Fallopian Tube

Heart - Atrial Appendage

Heart - Left Ventricle

Kidney - Cortex

Kidney - Medulla

Liver

Lung

Minor Salivary Gland

Muscle - Skeletal

Nerve - Tibial

Ovary

Pancreas

Pituitary

Prostate

Skin - Not Sun Exposed

Skin - Sun Exposed

Small Intestine - Terminal Ileum

Spleen

Stomach

Testis

Thyroid

Uterus

Vagina

Whole Blood

Pathways

Pathway	Source	External ID
Purine metabolism	KEGG	ko00230
Pyrimidine metabolism	KEGG	ko00240
Nicotinate and nicotinamide metabolism	KEGG	ko00760
Purine metabolism	KEGG	hsa00230
Pyrimidine metabolism	KEGG	hsa00240
Nicotinate and nicotinamide metabolism	KEGG	hsa00760
Metabolic pathways	KEGG	hsa01100
Metabolism	REACTOME	R-HSA-1430728
Metabolism of nucleotides	REACTOME	R-HSA-15869
Purine metabolism	REACTOME	R-HSA-73847
Purine catabolism	REACTOME	R-HSA-74259
Abacavir transport and metabolism	REACTOME	R-HSA-2161522
Abacavir metabolism	REACTOME	R-HSA-2161541

Protein levels (Protein atlas)

Not detected

Low

Medium

High

PharmGKB

Entity ID	Name	Type	Evidence	Association	PK	PD	PMIDs
PA445062	Neoplasms	Disease	ClinicalAnnotation	associated	PK		22838949, 24300978
PA447230	HIV	Disease	ClinicalAnnotation	associated		PD	23315321
PA449177	cytarabine	Chemical	VariantAnnotation	associated		PD
PA449301	didanosine	Chemical	ClinicalAnnotation	associated		PD	23315321
PA449748	gemcitabine	Chemical	ClinicalAnnotation	associated	PK		22838949, 24300978
PA450379	mercaptopurine	Chemical	MultilinkAnnotation	associated			15990089

References

Pubmed ID	Year	Title	Citations
38279611	2024	Schizophrenia risk proteins ZNF804A and NT5C2 interact in cortical neurons.	1
38279611	2024	Schizophrenia risk proteins ZNF804A and NT5C2 interact in cortical neurons.	1
36540014	2023	Silencing of circ-NT5C2 retards the progression of IL-1β-induced osteoarthritis in an in vitro cell model by targeting the miR-142-5p/NAMPT axis.	1
36540014	2023	Silencing of circ-NT5C2 retards the progression of IL-1β-induced osteoarthritis in an in vitro cell model by targeting the miR-142-5p/NAMPT axis.	1
35295960	2022	Associations between Gene-Gene Interaction and Overweight/Obesity of 12-Month-Old Chinese Infants.	0
35295960	2022	Associations between Gene-Gene Interaction and Overweight/Obesity of 12-Month-Old Chinese Infants.	0
32970317	2021	Enhanced migration of breast and lung cancer cells deficient for cN-II and CD73 via COX-2/PGE2/AKT axis regulation.	5
33124053	2021	Effects of NT5C2 Germline Variants on 6-Mecaptopurine Metabolism in Children With Acute Lymphoblastic Leukemia.	4
33434633	2021	CD73 and cN-II regulate the cellular response to chemotherapeutic and hypoxic stress in lung adenocarcinoma cells.	3
34209768	2021	Cytosolic 5'-Nucleotidase II Silencing in Lung Tumor Cells Regulates Metabolism through Activation of the p53/AMPK Signaling Pathway.	4
34636169	2021	NUDT15 polymorphism and NT5C2 and PRPS1 mutations influence thiopurine sensitivity in acute lymphoblastic leukaemia cells.	3
32970317	2021	Enhanced migration of breast and lung cancer cells deficient for cN-II and CD73 via COX-2/PGE2/AKT axis regulation.	5
33124053	2021	Effects of NT5C2 Germline Variants on 6-Mecaptopurine Metabolism in Children With Acute Lymphoblastic Leukemia.	4
33434633	2021	CD73 and cN-II regulate the cellular response to chemotherapeutic and hypoxic stress in lung adenocarcinoma cells.	3
34209768	2021	Cytosolic 5'-Nucleotidase II Silencing in Lung Tumor Cells Regulates Metabolism through Activation of the p53/AMPK Signaling Pathway.	4

Citation

Dessen P

NT5C2 (5-nucleotidase, cytosolic II)

Atlas Genet Cytogenet Oncol Haematol. 2007-02-01

Online version: http://atlasgeneticsoncology.org/gene/46089/nt5c2-(5-nucleotidase-cytosolic-ii)