Identity
HGNC
LOCATION
10q24.32
LOCUSID
ALIAS
GMP,NT5B,PNT5,SPG45,SPG65,cN-II
FUSION GENES
Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool
Other Information
Locus ID:
NCBI: 22978
MIM: 600417
HGNC: 8022
Ensembl: ENSG00000076685
Variants:
dbSNP: 22978
ClinVar: 22978
TCGA: ENSG00000076685
COSMIC: NT5C2
RNA/Proteins
Expression (GTEx)
Pathways
Protein levels (Protein atlas)
PharmGKB
| Entity ID | Name | Type | Evidence | Association | PK | PD | PMIDs |
|---|---|---|---|---|---|---|---|
| PA445062 | Neoplasms | Disease | ClinicalAnnotation | associated | PK | 22838949, 24300978 | |
| PA447230 | HIV | Disease | ClinicalAnnotation | associated | PD | 23315321 | |
| PA449177 | cytarabine | Chemical | VariantAnnotation | associated | PD | ||
| PA449301 | didanosine | Chemical | ClinicalAnnotation | associated | PD | 23315321 | |
| PA449748 | gemcitabine | Chemical | ClinicalAnnotation | associated | PK | 22838949, 24300978 | |
| PA450379 | mercaptopurine | Chemical | MultilinkAnnotation | associated | 15990089 |
References
| Pubmed ID | Year | Title | Citations |
|---|---|---|---|
| 38279611 | 2024 | Schizophrenia risk proteins ZNF804A and NT5C2 interact in cortical neurons. | 1 |
| 38279611 | 2024 | Schizophrenia risk proteins ZNF804A and NT5C2 interact in cortical neurons. | 1 |
| 36540014 | 2023 | Silencing of circ-NT5C2 retards the progression of IL-1β-induced osteoarthritis in an in vitro cell model by targeting the miR-142-5p/NAMPT axis. | 1 |
| 36540014 | 2023 | Silencing of circ-NT5C2 retards the progression of IL-1β-induced osteoarthritis in an in vitro cell model by targeting the miR-142-5p/NAMPT axis. | 1 |
| 35295960 | 2022 | Associations between Gene-Gene Interaction and Overweight/Obesity of 12-Month-Old Chinese Infants. | 0 |
| 35295960 | 2022 | Associations between Gene-Gene Interaction and Overweight/Obesity of 12-Month-Old Chinese Infants. | 0 |
| 32970317 | 2021 | Enhanced migration of breast and lung cancer cells deficient for cN-II and CD73 via COX-2/PGE2/AKT axis regulation. | 5 |
| 33124053 | 2021 | Effects of NT5C2 Germline Variants on 6-Mecaptopurine Metabolism in Children With Acute Lymphoblastic Leukemia. | 4 |
| 33434633 | 2021 | CD73 and cN-II regulate the cellular response to chemotherapeutic and hypoxic stress in lung adenocarcinoma cells. | 3 |
| 34209768 | 2021 | Cytosolic 5'-Nucleotidase II Silencing in Lung Tumor Cells Regulates Metabolism through Activation of the p53/AMPK Signaling Pathway. | 4 |
| 34636169 | 2021 | NUDT15 polymorphism and NT5C2 and PRPS1 mutations influence thiopurine sensitivity in acute lymphoblastic leukaemia cells. | 3 |
| 32970317 | 2021 | Enhanced migration of breast and lung cancer cells deficient for cN-II and CD73 via COX-2/PGE2/AKT axis regulation. | 5 |
| 33124053 | 2021 | Effects of NT5C2 Germline Variants on 6-Mecaptopurine Metabolism in Children With Acute Lymphoblastic Leukemia. | 4 |
| 33434633 | 2021 | CD73 and cN-II regulate the cellular response to chemotherapeutic and hypoxic stress in lung adenocarcinoma cells. | 3 |
| 34209768 | 2021 | Cytosolic 5'-Nucleotidase II Silencing in Lung Tumor Cells Regulates Metabolism through Activation of the p53/AMPK Signaling Pathway. | 4 |
Citation
Dessen P
NT5C2 (5-nucleotidase, cytosolic II)
Atlas Genet Cytogenet Oncol Haematol. 2007-02-01
Online version: http://atlasgeneticsoncology.org/gene/46089/nt5c2-(5-nucleotidase-cytosolic-ii)
