HSPBP1 (HSPA (Hsp70) binding protein 1)

2007-02-01  

Identity

HGNC
HSPBP1
LOCATION
19q13.42
LOCUSID
23640
ALIAS
FES1
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 23640
MIM: 612939
HGNC: 24989
Ensembl: ENSG00000133265

Variants:

dbSNP: 23640
ClinVar: 23640
TCGA: ENSG00000133265
COSMIC: HSPBP1

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000133265ENST00000255631Q9NZL4
ENSG00000133265ENST00000433386Q9NZL4
ENSG00000133265ENST00000585698K7EKM6
ENSG00000133265ENST00000585927K7EMM7
ENSG00000133265ENST00000587551K7EQQ0
ENSG00000133265ENST00000587922Q9NZL4
ENSG00000133265ENST00000587959K7EN20
ENSG00000133265ENST00000588971K7ERT9
ENSG00000133265ENST00000593263K7EL16

Expression (GTEx)

0
10
20
30
40
50
60
70
80
90
100
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Protein processing in endoplasmic reticulumKEGGko04141
Protein processing in endoplasmic reticulumKEGGhsa04141

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
353879782022HspBP1 is a dual function regulatory protein that controls both DNA repair and apoptosis in breast cancer cells.7
353879782022HspBP1 is a dual function regulatory protein that controls both DNA repair and apoptosis in breast cancer cells.7
337139582021HSPBP1 facilitates cellular RLR-mediated antiviral response by inhibiting the K48-linked ubiquitination of RIG-I.3
337139582021HSPBP1 facilitates cellular RLR-mediated antiviral response by inhibiting the K48-linked ubiquitination of RIG-I.3
322353962020The Co-Chaperone HspBP1 Is a Novel Component of Stress Granules that Regulates Their Formation.7
322353962020The Co-Chaperone HspBP1 Is a Novel Component of Stress Granules that Regulates Their Formation.7
307861162019HspBP1 and anti-HspBP1 levels in the serum of HIV-infected individuals are associated to the disease progression.3
307861162019HspBP1 and anti-HspBP1 levels in the serum of HIV-infected individuals are associated to the disease progression.3
284978972017Expression profile of heat shock proteins in placental tissues of patients with preterm prelabor rupture of membranes and spontaneous preterm labor with intact membranes.7
288479532017Differential HspBP1 expression accounts for the greater vulnerability of neurons than astrocytes to misfolded proteins.23
284978972017Expression profile of heat shock proteins in placental tissues of patients with preterm prelabor rupture of membranes and spontaneous preterm labor with intact membranes.7
288479532017Differential HspBP1 expression accounts for the greater vulnerability of neurons than astrocytes to misfolded proteins.23
265386022016HSP70 binding protein 1 (HspBP1) suppresses HIV-1 replication by inhibiting NF-κB mediated activation of viral gene expression.24
265386022016HSP70 binding protein 1 (HspBP1) suppresses HIV-1 replication by inhibiting NF-κB mediated activation of viral gene expression.24
244548602014Hsp70 cochaperones HspBP1 and BAG-1M differentially regulate steroid hormone receptor function.8

Citation

Dessen P

HSPBP1 (HSPA (Hsp70) binding protein 1)

Atlas Genet Cytogenet Oncol Haematol. 2007-02-01

Online version: http://atlasgeneticsoncology.org/gene/46091/hspbp1-(hspa-(hsp70)-binding-protein-1)