HSPBP1 (HSPA (Hsp70) binding protein 1)

Identity

HGNC

HSPBP1

LOCATION

19q13.42

LOCUSID

23640

ALIAS

FES1

FUSION GENES

Show Gene Fusions

Other Information

Locus ID:

NCBI: 23640
MIM: 612939
HGNC: 24989
Ensembl: ENSG00000133265

Variants:

dbSNP: 23640
ClinVar: 23640
TCGA: ENSG00000133265
COSMIC: HSPBP1

RNA/Proteins

Gene ID	Transcript ID	Uniprot
ENSG00000133265	ENST00000255631	Q9NZL4
ENSG00000133265	ENST00000433386	Q9NZL4
ENSG00000133265	ENST00000585698	K7EKM6
ENSG00000133265	ENST00000585927	K7EMM7
ENSG00000133265	ENST00000587551	K7EQQ0
ENSG00000133265	ENST00000587922	Q9NZL4
ENSG00000133265	ENST00000587959	K7EN20
ENSG00000133265	ENST00000588971	K7ERT9
ENSG00000133265	ENST00000593263	K7EL16

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Expression (GTEx)

0

10

20

30

40

50

60

70

80

90

100

Adipose - Subcutaneous

Adipose - Visceral

Adrenal Gland

Artery - Aorta

Artery - Tibial

Bladder

Brain - Amygdala

Brain - Anterior cingulate cortex

Brain - Caudate

Brain - Cerebellar Hemisphere

Brain - Cerebellum

Brain - Cortex

Brain - Frontal Cortex

Brain - Hippocampus

Brain - Hypothalamus

Brain - Nucleus accumbens

Brain - Putamen

Brain - Spinal cord

Brain - Substantia nigra

Breast - Mammary Tissue

Cells - Cultured fibroblasts

Cells - EBV - transformed lymphocytes

Cervix - Ectocervix

Cervix - Endocervix

Colon - Sigmoid

Colon - Transverse

Esophagus - Gastroesophageal Junction

Esophagus - Mucosa

Esophagus - Muscularis

Fallopian Tube

Heart - Atrial Appendage

Heart - Left Ventricle

Kidney - Cortex

Kidney - Medulla

Liver

Lung

Minor Salivary Gland

Muscle - Skeletal

Nerve - Tibial

Ovary

Pancreas

Pituitary

Prostate

Skin - Not Sun Exposed

Skin - Sun Exposed

Small Intestine - Terminal Ileum

Spleen

Stomach

Testis

Thyroid

Uterus

Vagina

Whole Blood

Pathways

Pathway	Source	External ID
Protein processing in endoplasmic reticulum	KEGG	ko04141
Protein processing in endoplasmic reticulum	KEGG	hsa04141

Protein levels (Protein atlas)

Not detected

Low

Medium

High

References

Pubmed ID	Year	Title	Citations
24454860	2014	Hsp70 cochaperones HspBP1 and BAG-1M differentially regulate steroid hormone receptor function.	8
26538602	2016	HSP70 binding protein 1 (HspBP1) suppresses HIV-1 replication by inhibiting NF-κB mediated activation of viral gene expression.	24
26538602	2016	HSP70 binding protein 1 (HspBP1) suppresses HIV-1 replication by inhibiting NF-κB mediated activation of viral gene expression.	24
28497897	2017	Expression profile of heat shock proteins in placental tissues of patients with preterm prelabor rupture of membranes and spontaneous preterm labor with intact membranes.	7
28497897	2017	Expression profile of heat shock proteins in placental tissues of patients with preterm prelabor rupture of membranes and spontaneous preterm labor with intact membranes.	7
28847953	2017	Differential HspBP1 expression accounts for the greater vulnerability of neurons than astrocytes to misfolded proteins.	23
28847953	2017	Differential HspBP1 expression accounts for the greater vulnerability of neurons than astrocytes to misfolded proteins.	23
30786116	2019	HspBP1 and anti-HspBP1 levels in the serum of HIV-infected individuals are associated to the disease progression.	3
30786116	2019	HspBP1 and anti-HspBP1 levels in the serum of HIV-infected individuals are associated to the disease progression.	3
32235396	2020	The Co-Chaperone HspBP1 Is a Novel Component of Stress Granules that Regulates Their Formation.	7

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Citation

Dessen P

HSPBP1 (HSPA (Hsp70) binding protein 1)

Atlas Genet Cytogenet Oncol Haematol. 2007-02-01

Online version: http://atlasgeneticsoncology.org/gene/46091/hspbp1-(hspa-(hsp70)-binding-protein-1)