DPEP1 (dipeptidase 1)

2007-02-01  

Identity

HGNC
DPEP1
LOCATION
16q24.3
LOCUSID
1800
ALIAS
MBD1,MDP,RDP
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 1800
MIM: 179780
HGNC: 3002
Ensembl: ENSG00000015413

Variants:

dbSNP: 1800
ClinVar: 1800
TCGA: ENSG00000015413
COSMIC: DPEP1

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000015413ENST00000261615P16444
ENSG00000015413ENST00000261615A0A140VJI3
ENSG00000015413ENST00000393092P16444
ENSG00000015413ENST00000393092A0A140VJI3
ENSG00000015413ENST00000421184P16444
ENSG00000015413ENST00000421184A0A140VJI3
ENSG00000015413ENST00000568281H3BP43
ENSG00000015413ENST00000570029H3BQS5

Expression (GTEx)

0
50
100
150
200
250
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
MetabolismREACTOMER-HSA-1430728
Metabolism of lipids and lipoproteinsREACTOMER-HSA-556833
Arachidonic acid metabolismREACTOMER-HSA-2142753
Synthesis of Leukotrienes (LT) and Eoxins (EX)REACTOMER-HSA-2142691
Biological oxidationsREACTOMER-HSA-211859
Aflatoxin activation and detoxificationREACTOMER-HSA-5423646

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
386265442024Dipeptidase 1 promotes ferroptosis in renal tubular epithelial cells in diabetic nephropathy via inhibition of the GSH/GPX4 axis.0
386265442024Dipeptidase 1 promotes ferroptosis in renal tubular epithelial cells in diabetic nephropathy via inhibition of the GSH/GPX4 axis.0
356700122023DPEP1 promotes drug resistance in colon cancer cells by forming a positive feedback loop with ASCL2.9
356700122023DPEP1 promotes drug resistance in colon cancer cells by forming a positive feedback loop with ASCL2.9
342915622021The relationship between common variants in the DPEP1 gene and the susceptibility and clinical severity of osteoarthritis.2
344265782021A single genetic locus controls both expression of DPEP1/CHMP1A and kidney disease development via ferroptosis.31
342915622021The relationship between common variants in the DPEP1 gene and the susceptibility and clinical severity of osteoarthritis.2
344265782021A single genetic locus controls both expression of DPEP1/CHMP1A and kidney disease development via ferroptosis.31
320682542020DPEP1 expression promotes proliferation and survival of leukaemia cells and correlates with relapse in adults with common B cell acute lymphoblastic leukaemia.6
320682542020DPEP1 expression promotes proliferation and survival of leukaemia cells and correlates with relapse in adults with common B cell acute lymphoblastic leukaemia.6
315410792019DPEP1 is a direct target of miR-193a-5p and promotes hepatoblastoma progression by PI3K/Akt/mTOR pathway.26
315410792019DPEP1 is a direct target of miR-193a-5p and promotes hepatoblastoma progression by PI3K/Akt/mTOR pathway.26
268249872016Dehydropeptidase 1 promotes metastasis through regulation of E-cadherin expression in colon cancer.15
268249872016Dehydropeptidase 1 promotes metastasis through regulation of E-cadherin expression in colon cancer.15
263924082015Reintroduction of a Homocysteine Level-Associated Allele into East Asians by Neanderthal Introgression.6

Citation

Dessen P

DPEP1 (dipeptidase 1)

Atlas Genet Cytogenet Oncol Haematol. 2007-02-01

Online version: http://atlasgeneticsoncology.org/gene/46097/dpep1-(dipeptidase-1)