LRP6 (LDL receptor related protein 6)

2003-02-01  

Identity

HGNC
LOCATION
12p13.2
LOCUSID
ALIAS
ADCAD2,STHAG7
FUSION GENES

Other Information

Locus ID:

NCBI: 4040
MIM: 603507
HGNC: 6698
Ensembl: ENSG00000070018

Variants:

dbSNP: 4040
ClinVar: 4040
TCGA: ENSG00000070018
COSMIC: LRP6

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000070018ENST00000261349O75581
ENSG00000070018ENST00000535731F5H0Z3
ENSG00000070018ENST00000538239H0YGW5
ENSG00000070018ENST00000540527H0YGH0
ENSG00000070018ENST00000543091F5H7J9

Expression (GTEx)

0
5
10
15
20
25
30

Pathways

PathwaySourceExternal ID
mTOR signaling pathwayKEGGko04150
Wnt signaling pathwayKEGGko04310
mTOR signaling pathwayKEGGhsa04150
Wnt signaling pathwayKEGGhsa04310
DiseaseREACTOMER-HSA-1643685
Diseases of signal transductionREACTOMER-HSA-5663202
Signaling by WNT in cancerREACTOMER-HSA-4791275
RNF mutants show enhanced WNT signaling and proliferationREACTOMER-HSA-5340588
Signal TransductionREACTOMER-HSA-162582
Signaling by WntREACTOMER-HSA-195721
TCF dependent signaling in response to WNTREACTOMER-HSA-201681
Disassembly of the destruction complex and recruitment of AXIN to the membraneREACTOMER-HSA-4641262
Regulation of FZD by ubiquitinationREACTOMER-HSA-4641263
Negative regulation of TCF-dependent signaling by WNT ligand antagonistsREACTOMER-HSA-3772470
Breast cancerKEGGko05224
Breast cancerKEGGhsa05224

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
382501522024The inhibition of YTHDF3/m(6)A/LRP6 reprograms fatty acid metabolism and suppresses lymph node metastasis in cervical cancer.1
382501522024The inhibition of YTHDF3/m(6)A/LRP6 reprograms fatty acid metabolism and suppresses lymph node metastasis in cervical cancer.1
366381822023A genetic variant of the Wnt receptor LRP6 accelerates synapse degeneration during aging and in Alzheimer's disease.7
366941342023LRP6/filamentous-actin signaling facilitates osteogenic commitment in mechanically induced periodontal ligament stem cells.4
369252292023Overexpression of circRNAs LRP6 in gestational diabetes mellitus predicts foetal malformation and intrauterine death.0
372027752023LRP5-/6 gene polymorphisms and its association with risk of abnormal bone mass in postmenopausal women.0
366381822023A genetic variant of the Wnt receptor LRP6 accelerates synapse degeneration during aging and in Alzheimer's disease.7
366941342023LRP6/filamentous-actin signaling facilitates osteogenic commitment in mechanically induced periodontal ligament stem cells.4
369252292023Overexpression of circRNAs LRP6 in gestational diabetes mellitus predicts foetal malformation and intrauterine death.0
372027752023LRP5-/6 gene polymorphisms and its association with risk of abnormal bone mass in postmenopausal women.0
348966072022Variants in the Wnt co-receptor LRP6 are associated with familial exudative vitreoretinopathy.12
352117552022circ‑LRP6 contributes to osteosarcoma progression by regulating the miR‑141‑3p/HDAC4/HMGB1 axis.6
352776572022SIK2 maintains breast cancer stemness by phosphorylating LRP6 and activating Wnt/β-catenin signaling.9
358406982022An LRP6 mutation (Arg360His) associated with low bone mineral density but not cardiovascular events in a Caucasian family.2
359612352022Mutations in LRP6 highlight the role of WNT signaling in oral exostoses and dental anomalies.8

Citation

Dessen P

LRP6 (LDL receptor related protein 6)

Atlas Genet Cytogenet Oncol Haematol. 2003-02-01

Online version: http://atlasgeneticsoncology.org/gene/461/lrp6-(ldl-receptor-related-protein-6)