COMP (cartilage oligomeric matrix protein)

2007-02-01  

Identity

HGNC
LOCATION
19p13.11
LOCUSID
ALIAS
CTS2,EDM1,EPD1,MED,PSACH,THBS5,TSP5
FUSION GENES

Other Information

Locus ID:

NCBI: 1311
MIM: 600310
HGNC: 2227
Ensembl: ENSG00000105664

Variants:

dbSNP: 1311
ClinVar: 1311
TCGA: ENSG00000105664
COSMIC: COMP

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000105664ENST00000222271P49747
ENSG00000105664ENST00000425807P49747
ENSG00000105664ENST00000542601G3XAP6

Expression (GTEx)

0
100
200
300
400
500
600

Pathways

PathwaySourceExternal ID
Focal adhesionKEGGko04510
ECM-receptor interactionKEGGko04512
Focal adhesionKEGGhsa04510
ECM-receptor interactionKEGGhsa04512
MalariaKEGGko05144
MalariaKEGGhsa05144
PhagosomeKEGGko04145
PhagosomeKEGGhsa04145
PI3K-Akt signaling pathwayKEGGhsa04151
PI3K-Akt signaling pathwayKEGGko04151
Extracellular matrix organizationREACTOMER-HSA-1474244
ECM proteoglycansREACTOMER-HSA-3000178
Integrin cell surface interactionsREACTOMER-HSA-216083

References

Pubmed IDYearTitleCitations
199131212009Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip.85
171952162007Sex and ethnic differences in the association of ASPN, CALM1, COL2A1, COMP, and FRZB with genetic susceptibility to osteoarthritis of the knee.53
160516042005Cartilage oligomeric matrix protein/thrombospondin 5 supports chondrocyte attachment through interaction with integrins.51
175889492007Interaction of cartilage oligomeric matrix protein/thrombospondin 5 with aggrecan.42
222416092012Chondrogenic differentiation of induced pluripotent stem cells from osteoarthritic chondrocytes in alginate matrix.39
191252862009Changes in serum cartilage oligomeric matrix protein (COMP), plasma CPK and plasma hs-CRP in relation to running distance in a marathon (42.195 km) and an ultra-marathon (200 km) race.38
122258112002Matrix-matrix interaction of cartilage oligomeric matrix protein and fibronectin.36
118916742001Pseudoachondroplasia and multiple epiphyseal dysplasia: New etiologic developments.35
156941292005COMP mutations, chondrocyte function and cartilage matrix.35
188556212008The role of cartilage oligomeric matrix protein (COMP) in skeletal disease.32

Citation

Dessen P

COMP (cartilage oligomeric matrix protein)

Atlas Genet Cytogenet Oncol Haematol. 2007-02-01

Online version: http://atlasgeneticsoncology.org/gene/46113/comp-(cartilage-oligomeric-matrix-protein)