SNCA (synuclein alpha)

2007-02-01  

Identity

HGNC
SNCA
LOCATION
4q22.1
LOCUSID
6622
ALIAS
NACP,PARK1,PARK4,PD1
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 6622
MIM: 163890
HGNC: 11138
Ensembl: ENSG00000145335

Variants:

dbSNP: 6622
ClinVar: 6622
TCGA: ENSG00000145335
COSMIC: SNCA

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000145335ENST00000336904P37840
ENSG00000145335ENST00000345009P37840
ENSG00000145335ENST00000345009H6UYS5
ENSG00000145335ENST00000394986P37840
ENSG00000145335ENST00000394989P37840
ENSG00000145335ENST00000394989H6UYS0
ENSG00000145335ENST00000394991P37840
ENSG00000145335ENST00000420646P37840
ENSG00000145335ENST00000420646H6UYS5
ENSG00000145335ENST00000502987E7EPV7
ENSG00000145335ENST00000505199P37840
ENSG00000145335ENST00000505199H6UYS0
ENSG00000145335ENST00000506244P37840
ENSG00000145335ENST00000506691D6RA31
ENSG00000145335ENST00000508895P37840
ENSG00000145335ENST00000611107H6UYS7
ENSG00000145335ENST00000618500P37840
ENSG00000145335ENST00000618500H6UYS0

Expression (GTEx)

0
50
100
150
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Alzheimer's diseaseKEGGko05010
Alzheimer's diseaseKEGGhsa05010
Parkinson's diseaseKEGGhsa05012
Metabolism of proteinsREACTOMER-HSA-392499
Amyloid fiber formationREACTOMER-HSA-977225

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
356575772024Disease Mechanisms of Multiple System Atrophy: What a Parallel Between the Form of Pasta and the Alpha-Synuclein Assemblies Involved in MSA and PD Tells Us.0
376716152024MerTK is a mediator of alpha-synuclein fibril uptake by human microglia.1
377143262024Calcium influx: An essential process by which α-Synuclein regulates morphology of erythrocytes.1
379955102024Selenium and selenoproteins role in Parkinson's disease: Is there a link between selenoproteins and accumulated alpha-synuclein?0
380436772024Young human alpha synuclein transgenic (BAC-SNCA) mice display sex- and gene-dose-dependent phenotypic disturbances.0
380480872024Neuronally Derived Extracellular Vesicle α-Synuclein as a Serum Biomarker for Individuals at Risk of Developing Parkinson Disease.8
381049572024Revisiting the role of 3-nitrotyrosine residues in the formation of alpha-synuclein oligomers and fibrils.0
381056192024Alpha-synuclein promotes PRMT5-mediated H4R3me2s histone methylation by interacting with the BAF complex.1
381636472024Extracellular α-synuclein impairs sphingosine 1-phosphate receptor type 3 (S1PR3)-regulated lysosomal delivery of cathepsin D in HeLa cells.0
382507742024Misfolded α-Synuclein in Autosomal Dominant Alzheimer's Disease.0
382562072024The 75-99 C-Terminal Peptide of URG7 Protein Promotes α-Synuclein Disaggregation.0
382704422024Misfolded alpha-synuclein in amyotrophic lateral sclerosis: Implications for diagnosis and treatment.1
382912302024Dopaminergic neuron loss in mice due to increased levels of wild-type human α-Synuclein only takes place under conditions of accelerated aging.0
383073022024Alpha-synuclein pathology is associated with astrocyte senescence in a midbrain organoid model of familial Parkinson's disease.2
383352812024Sequential CRISPR screening reveals partial NatB inhibition as a strategy to mitigate alpha-synuclein levels in human neurons.1

Citation

Dessen P

SNCA (synuclein alpha)

Atlas Genet Cytogenet Oncol Haematol. 2007-02-01

Online version: http://atlasgeneticsoncology.org/gene/46121/snca-(synuclein-alpha)